Reference

Quantitation of chlorpropamide and tolbutamide in tablets by stability-indicating reverse phase high-performance liquid chromatography

Quantitation of chlorpropamide and tolbutamide in tablets by stability-indicating reverse phase high-performance liquid chromatography. Das Gupta, V. (Dep. Pharm., Univ. Houston, Houston, TX 77030, USA). Anal. Lett., 17(B18), 2119-28 (English) 1984. CODEN: ANALBP. ISSN: 0003-2719. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 A stability-indicating assay method for the quantitation of chloropropamide (I) [94-20-2] and tolbutamide (II) [64-77-7] based on reversed phase HPLC was developed. The method is accurate, reproducible and precise with a percent relative std. deviations based on 5 readings of 0.52 and 0.46 for I and II, resp. There is no interference from the products of hydrolysis of I or II (they elute before the intact drug) and the excipients present in the tablets. The hydrolysis process proceeds quickly in acidic pH as compared with basic pH. The products of hydrolysis, p-chlorobenzenesulfonamide [98-64-6] (from I) and p-toluenesulfonamide [70-55-3] (from II) can also be quantified if required. The hydrolysis of both I and II in 0.09N H2SO4 followed first order law with K values of 0.0036 and 0.0047 per day (at 50°), resp.

Possible use of synthetic polymer adsorbents for the removal of organic compounds from wastewaters

Possible use of synthetic polymer adsorbents for the removal of organic compounds from wastewaters. Koganovskii, A. M.; Levchenko, T. M.; Podlesnyuk, V. V. (USSR). Visn. Akad. Nauk Ukr. RSR, (10), 44-8 (Ukrainian) 1983. CODEN: VNUKAC. ISSN: 0372-6436. DOCUMENT TYPE: Journal CA Section: 60 (Waste Treatment and Disposal) Section cross-reference(s): 49 Treatment in a system consisting of 3 in-series adsorption columns filled with Polysorb 44-100 [9003-70-7] (a divinylbenzene [1321-74-0]-contg. polymer allows 100% removal of org. compds. from wastewaters and recovery of materials removed. The sorbent is readily regenerated by EtOH [64-17-5] in 2 steps. The spent EtOH is distd.There are some commonly used reagents with their cas registry numbers 106-47-8 and 100-01-6 in this article. and recycled into the prodn. process. The system is highly suitable for treating p-chlorobenzenesulfamide (I) [98-64-6]-manufg. wastewaters to remove I. The adsorption characteristics of the Polysorb are significantly higher than those of activated C. .