Detail of "98495-35-3"

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Comparison of the effects of FMRF-amide and pQDPFLRF-amide on identified Helix neurons

Comparison of the effects of FMRF-amide and pQDPFLRF-amide on identified Helix neurons. Boyd, P. J.; Walker, R. J. (Dep. Neurophysiol., Univ. Southampton, Southampton SO9 3TU, UK). Comp. Biochem. Physiol., C: Comp. Pharmacol.Several substances with their cas registry numbers 64190-70-1 and 98495-35-3 may be metioned in this study. Toxicol., 86C(2), 371-3 (English) 1987. CODEN: CBPCEE. ISSN: 0742-8413. DOCUMENT TYPE: Journal CA Section: 12 (Nonmammalian Biochemistry) Intracellular recordings were made from a selection of identified neurons in the subesophageal ganglia of H. aspersa, and their responses to the mollusk neuropeptides FMRF-amide (H-Phe-Met-Arg-Phe-NH2) and pQDPFLRF-amide (H-pGlu-Asp-Pro-Phe-Leu-Arg-Phe-NH2) compared. Whereas FMRF-amide excited certain neurons and inhibited others, pQDPFLRF-amide did not produce excitation in any of the cells tested. A few cells were unresponsive to pQDPFLRF-amide, but most were inhibited with varying potency. FMRF-amide was generally 10-100-fold more potent than pQDPFLRF-amide, but 1 cell, E13 in the visceral ganglion, showed equal sensitivity to the 2 peptides. On most cells there was no clear evidence for cross-desensitization between the 2 peptides, although it is possible that in some cases where both peptides are inhibitory they may be acting on a single receptor. .