Detail of "98824-26-1"

Reference

Structure and expression of the human calcitonin/CGRP genes

Structure and expression of the human calcitonin/CGRP genes. Steenbergh, P. H.; Hoppener, J. W. M.; Zandberg, J.; Visser, A.; Lips, C. J. M.; Jansz, H. S. (Inst. Mol. Biol., Utrecht 3508 TB, Neth.). FEBS Lett., 209(1), 97-103 (English) 1986. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) Section cross-reference(s): 2, 13 The isolation of cDNA encoding a 2nd human calcitonin gene-related peptide (hCGRP-II) [98824-26-1] was previously reported. The isolation and characterization of the gene encoding hCGRP-II are described. This gene, designated CALC-II, is structurally closely related to the known CALC-I gene encoding human calcitonin (hCT) and hCGRP-I. In contrast to CALC-I, CALC-II does not seem to be alternatively expressed. The formation of a 2nd, hCT-like mRNA by differential splicing of CALC-II transcripts is unlikely in view of the structure of CALC-II, and could not be demonstrated in tissues known to express CALc-I and CALC-II.

Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord

Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. Petermann, Josef B.; Born, Walter; Chang, Jui Yoa; Fischer, Jan A. (Dep. Orthop. Surg., Univ. Zurich, Zurich 8008, Switz.). J. Biol. Chem., 262(2), 542-5 (English) 1987. CODEN: JBCHA3. ISSN: 0021-9258. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) Section cross-reference(s): 13 Two human genes encoding precursors for 2 calcitonin gene-related peptides (CGRP) I (or a) [83652-28-2] and II (or b) [98824-26-1] have been identified. The amino acid sequence of CGRP-I was obtained in medullary thyroid carcinoma exts., but not in normal human tissues. The human CGRP-II peptide remained to be discovered. The amino acid compn. and the partial amino acid sequence of the DNA-predicted CGRP-I and -II in the human spinal cord are presented. The data indicate for the first time the existence of a second CGRP different from the known CGRP-I. CGRP-II has been identified in the central nervous system, pituitary, thyroid, and in medullary thyroid carcinoma as a major CGRP form together with CGRP-I.