Detail of "99-08-1"

Reference

An outdoor smog chamber and modeling study of toluene-NOx photooxidation

An outdoor smog chamber and modeling study of toluene-NOx photooxidation. Leone, Joseph A.; Flagan, Richard C.; Grosjean, Daniel; Seinfeld, John H. (Dep. Chem. Eng., California Inst. Technol., Pasadena, CA 91125, USA). Int. J. Chem. Kinet., 17(2), 177-216 (English) 1985. CODEN: IJCKBO. ISSN: 0538-8066. DOCUMENT TYPE: Journal CA Section: 59 (Air Pollution and Industrial Hygiene) Section cross-reference(s): 74 An exptl. investigation of the gas-phase photooxidn. of PhMe [108-88-3]-NOx-air mixts. at part-per-million concns. was done in a 65-m3 outdoor smog chamber to assess the atm. chem. of PhMe. In addn., 6 CO-NOx-air irradiations were conducted to characterize the chamber with regard to any wall radical sources. Measured parameters in the PhMe-NOx expts. included O3, NO, NO2, HNO3, peroxyacetyl nitrate [2278-22-0], CO, PhMe, benzaldehyde [100-52-7], o-cresol [95-48-7], m-nitrotoluene [99-08-1], peroxybenzoyl nitrate [32368-69-7], temp., relative humidity, aerosol size distributions, and particulate org. C. Predictions of the reaction mechanism of J. A. Leone and J. H. Seinfeld (1984) are found to be in good agreement with the data under a variety of initial conditions. Addnl. simulations are used to investigate various mechanistic pathways in areas where our understanding of PhMe chem. is still incomplete.

Hepatic macromolecular covalent binding of mononitrotoluenes in Fischer-344 rats

Hepatic macromolecular covalent binding of mononitrotoluenes in Fischer-344 rats. Rickert, Douglas E.; Long, Rochelle M.; Dyroff, Martin C.; Kedderis, Gregory L. (Dep. Gen. Biochem. Toxicol., Chem. Ind. Inst. Toxicol., Research Triangle Park, NC 27709, USA). Chem.-Biol. Interact., 52(2), 131-9 (English) 1984. CODEN: CBINA8. ISSN: 0009-2797. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) To det. whether hepatic macromol. covalent binding of the mononitrotoluene isomers (I) differed and whether covalent binding of I to hepatic DNA in vivo was decreased by inhibitors of sulfotransferase [9023-09-0]. Male Fischer-344 rats were given a single oral dose of ring-U-14C-labeled 2- [88-72-2], 3- [99-08-1], or 4-nitrotoluene [99-99-0] (2-, 3-, or 4-NT) and killed at various times thereafter. Livers were removed and analyzed for total and covalently bound radiolabel. Maximal concns. of total radiolabel were obsd. between 3 and 12 h after the dose, and there were no large differences among the 3 isomers in peak concns. achieved. Covalent binding to hepatic macromols. was maximal 12 h after administration for all 3 isomers. Thereafter, concns. of covalently bound 2-NT-derived material were always 2-6 times higher than those of 3- or 4-NT-derived material. When DNA was isolated from livers of rats given I 12 h previously, only 2-NT was obsd. to covalently bind at concns. above the limits of detection of the assay. The covalent binding of 2-NT, but not that of 3- or 4-NT, to both total hepatic macromols. and DNA was markedly decreased by prior administration of PCP or DCNP. Covalent binding to hepatic DNA was decreased by >96%. Thus, 2-NT, but not 3- or 4-NT, induces DNA excision repair. Furthermore, 2-NT, like the hepatocarcinogen 2,6-dinitrotoluene, may require the action of sulfotransferase for its conversion to a species capable of covalently binding to hepatic DNA.