Reference

Thermogravimetric determination of basic and intermediary substances in cosmetics

Thermogravimetric determination of basic and intermediary substances in cosmetics. Lorant, Bela (Inst. State Control Nutr. Chem., Budapest, Hung.). Seifen, Oele, Fette, Wachse, 103(14), 393-6 (German) 1977. CODEN: SOFWAF. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Heteropoly acid complexes of org. amino compds. used in cosmetics were prepd. for thermogravimetric detn. of these constituents. The amines formed complexes easily with H3P(W3O10)4; H3P(Mo3O10)4; H4Si(Mo3O10)4; and H4Si(W3O10)4 which pptd. quant., and were easily filtrable. The complexes lost their H2O of crystn. at 200.degree. and became stabilized. Most of the complexes decompd. at .gtoreq.600.degree.. Residual H2O, and then the amines themselves were quant. detd. by thermogravimetric anal. For example, m-nitroaniline [99-09-2], morpholine [110-91-8], triethanolamine [102-71-6], and other basic amines were analyzed by this method.

Synthesis and antitumor properties of bis(quinaldine) derivatives

Synthesis and antitumor properties of bis(quinaldine) derivatives. Sinha, Birandra K.; Philen, R. M.; Sato, R.; Cysyk, R. L. (Org. Chem. Div., Microbiol. Assoc., Bethesda, Md., USA). J. Med. Chem., 20(11), 1528-31 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 27 Condensation of m-nitroaniline [99-09-2] with Et acetoacetate [141-97-9] followed by cyclization and sepn. of isomers by selective soly. in Me2SO gave 7-nitro-2-methyl-4-(1H)quinolone [64334-95-8], which reacted with POCl3 to give 7-nitro-4-chloro-2-methylquinoline [56983-09-6], which reacted with the appropriate di- and triamines to give 5 bis(7-nitro-4-quinaldinyl)-.alpha.,.omega.-diaminoalkanes. Three of the 7-nitro derivs., I [64335-06-4], II [64335-07-5], and III [64335-08-6], were moderately active in the mouse P-388 lymphocytic leukemia screen. Redn. of the nitro compds. gave IV [64335-01-9], V [64335-02-0], VI [64335-03-1], VII [64335-04-2], and VIII [64335-05-3], which were moderately to strongly active in the P-388 screen, bound to the DNA helix and stabilized it against temp.Several substances like 64334-93-6 may be metioned in this study. denaturation, and inhibited DNA-dependent RNA polymerase [9014-24-8]. .