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| CAS No.: | 99-98-9 |
|---|---|
| Name: | N,N-Dimethyl-1,4-phenylenediamine |
| Article Data: | 241 |
| Molecular Structure: | |
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| Formula: | C8H12N2 |
| Molecular Weight: | 136.197 |
| Synonyms: | 1,4-Benzenediamine,N,N-dimethyl- (9CI);p-Phenylenediamine, N,N-dimethyl- (8CI);1-Amino-4-(dimethylamino)benzene;4-(Dimethylamine)aniline;4-(Dimethylamino)aniline;4-(Dimethylamino)benzenamine;4-(N,N-Dimethylamino)aniline;4-(N,N-Dimethylamino)phenylamine;4-Amino-N,N-dimethylaniline;C.I. 76075;DMPD;Dimethyl-p-phenylenediamine;N,N-Dimethyl-1,4-benzenediamine;N,N-Dimethyl-1,4-diaminobenzene;N,N-Dimethyl-1,4-phenylenediamine;N,N-Dimethyl-p-benzenediamine;N,N-Dimethyl-p-phenylenediamine;N-(4-Aminophenyl)-N,N-dimethylamine;NSC 1493;[4-(Dimethylamino)phenyl]amine;p-(Dimethylamino)aniline;p-(Dimethylamino)phenylamine;p-Amino-N,N-dimethylaniline;p-Aminodimethylaniline; |
| EINECS: | 202-807-5 |
| Density: | 1.049 g/cm |
| Melting Point: | 34-36 °C(lit.) |
| Boiling Point: | 262 °C at 760 mmHg |
| Flash Point: | 88.6 °C |
| Solubility: | 11 g/L (20 °C ) in water |
| Appearance: | grey to black solid |
| Hazard Symbols: |
 T
|
| Risk Codes: | 23/24/25-36/37/38 |
| Safety: | 28-45-36/37/39-26 |
| Transport Information: | UN 2811 6.1/PG 2 |
| PSA: | 29.26000 |
| LogP: | 1.91600 |
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Chemistry
IUPAC Name: 1-N,1-N-dimethylbenzene-1,4-diamine
Empirical Formula: C8H12N2
Molecular Weight: 136.1943g/mol
EINECS: 202-807-5
Structure of 1,4-Benzenediamine,N1,N1-dimethyl- (CAS NO.99-98-9):
Index of Refraction: 1.607
Molar Refractivity: 44.8 cm3
Molar Volume: 129.7 cm3
Polarizability: 17.76×10-24cm3
Surface Tension: 44.5 dyne/cm
Density: 1.049 g/cm3
Flash Point: 88.6 °C
Enthalpy of Vaporization: 49.98 kJ/mol
Melting Point: 34-36 °C(lit.)
Boiling Point: 262 °C at 760 mmHg
Vapour Pressure: 0.0112 mmHg at 25°C
Physical Appearance: grey to black solid
Product Categories: Amines
Canonical SMILES: CN(C)C1=CC=C(C=C1)N
InChI: InChI=1S/C8H12N2/c1-10(2)8-5-3-7(9)4-6-8/h3-6H,9H2,1-2H3
InChIKey: BZORFPDSXLZWJF-UHFFFAOYSA-N
Uses
Used in the production of methylene blue and photographic developer. Used as a chemical intermediate for dyes and diazonium chloride salts and as an analytical reagent to detect chloroamine in water.
Production
N,N-Dimethyl-1,4-phenylenediamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Incompatible with strong oxidizers, strong acids and acid anhydrides. Also incompatible with alkalis .
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | oral | 20mg/kg (20mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| dog | LDLo | intraperitoneal | 10mg/kg (10mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 262, 1949. |
| dog | LDLo | intravenous | 51mg/kg (51mg/kg) | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. | |
| dog | LDLo | skin | 84mg/kg (84mg/kg) | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. | |
| guinea pig | LCLo | inhalation | 240ppb (0.24ppm) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| guinea pig | LD50 | intraperitoneal | 45mg/kg (45mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 262, 1949. |
| guinea pig | LD50 | skin | 500uL/kg (0.5mL/kg) | National Technical Information Service. Vol. OTS0555326, | |
| guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| human | TDLo | skin | 14ug/kg (0.014mg/kg) | BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE" | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| mouse | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 262, 1949. | |
| mouse | LD50 | oral | 30mg/kg (30mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | National Technical Information Service. Vol. OTS0555326, |
| rabbit | LCLo | inhalation | 500ppb (0.5ppm) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| rabbit | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 262, 1949. |
| rabbit | LDLo | oral | 150mg/kg (150mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| rabbit | LDLo | skin | 60mg/kg (60mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| rabbit | LDLo | subcutaneous | 60mg/kg (60mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
| rat | LD50 | intraperitoneal | 21mg/kg (21mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 262, 1949. |
| rat | LD50 | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | National Technical Information Service. Vol. OTS0555326, |
| rat | LDLo | subcutaneous | 50mg/kg (50mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
Safety Profile
Hazard Codes: 
T
Risk Statements: 23/24/25-36/37/38
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 28-45-36/37/39-26
S28:After contact with skin, wash immediately with plenty of soap-suds.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: ST0874000
F: 8-10-23
Hazard Note: Toxic/Keep Cold
HazardClass: 6.1
PackingGroup: II
Hazardous Substances Data: 99-98-9(Hazardous Substances Data)
Specification
1,4-Benzenediamine,N1,N1-dimethyl- , its cas register number is 99-98-9. It also can be called 4-(Dimethylamino)aniline ;
4-(Dimethylamino)benzenamine ; 4-(Dimethylamino)phenylamine ; 4-Amino-N,N-dimethylaniline ; AI3-52360 ; C.I. 76075 ;
CCRIS 6024 ; CI 76075 ; DMPD ; Dimethyl-p-phenylenediamine ; Dimethyl-para-phenylenediamine ; HSDB 5330 ; N,N'-Dimethyl-P-phenylenediamine ; N,N-Dimethyl-p-benzenediamine ; N,N-Dimethyl-p-fenylendiamin ; N,N-Dimethyl-p-phenylenediamine ; NSC 1493 ; p-(Dimethylamino)aniline ; p-Amino-N,N-dimethylaniline ; p-Aminodimethylaniline ; p-Dimethylaminophenylamine ; p-Phenylenediamine, N,N-dimethyl- .