CAS No.99464-64-9,Ampiroxicam Suppliers

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Basic Information

Molecular Structure:
CAS No.:	99464-64-9
Name:	Ampiroxicam
Article Data:	2

Formula:	C₂₀H₂₁N₃O₇S
Molecular Weight:	447.469
Synonyms:	ethyl 1-[[9-methyl-10,10-dioxo-8-(pyridin-2-ylcarbamoyl)-10$l^{6}-thia-9-azabicyclo[4.4.0]deca-1,3,5,7-tetraen-7-yl]oxy]ethyl carbonate;Ampiroxicamum [Latin];Flucam (TN);Flucam;(+-)-4-(1-Hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester), 1,1-dioxide;Ampiroxicam (+-);Ampiroxicam (JAN);Carbonic acid, ethyl 1-((2-methyl-3-((2-pyridinylamino)carbonyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl ester, S,S-dioxide;Ampiroxicam [BAN:INN:JAN];Carbonic acid,esters,ethyl 1-[[2-methyl-1,1-dioxido-3-[(2- pyridinylamino)carbonyl]-2H-1,2- benzothiazin-4-yl]oxy]ethyl ester;CP 65703;Ampiroxicam 99%;Ampiroxicamum;
EINECS:	807-877-6
Density:	1.44 g/cm³
Melting Point:	159-161?C
Appearance:	Powder
PSA:	132.51000
LogP:	3.65040

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Chemistry

IUPAC Name: Ethyl 1-[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)benzo[e]thiazin-4-yl]oxyethyl carbonate
Molecular Formula: C₂₀H₂₁N₃O₇S
Molecular Weight: 447.46 g/mol
SMILES: c1(NC(C2=C(c3c(cccc3)S(=O)(=O)N2C)O[C@@H](OC(OCC)=O)C)=O)ccccn1
InChI: InChI=1/C20H21N3O7S/c1-4-28-20(25)30-13(2)29-18-14-9-5-6-10-15(14)31(26,27)23(3)17(18)19(24)22-16-11-7-8-12-21-16/h5-13H,4H2,1-3H3,(H,21,22,24)
Classification Code: Drug / Therapeutic Agent; Reproductive Effect
XLogP3: 4
H-Bond Donor: 1
H-Bond Acceptor: 9
Index of Refraction: 1.629
Molar Refractivity: 110.12 cm³
Molar Volume: 309.6 cm³
Polarizability: 43.65×10^-24 cm³
Surface Tension: 67 dyne/cm
Density of Ampiroxicam (CAS NO.99464-64-9): 1.44 g/cm³

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	oral	> 500mg/kg (500mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 432, 1994.
mouse	LD50	intraperitoneal	1358mg/kg (1358mg/kg)		Drugs in Japan Vol. -, Pg. 119, 1995.
mouse	LD50	oral	2291mg/kg (2291mg/kg)		Drugs in Japan Vol. -, Pg. 119, 1995.
mouse	LD50	subcutaneous	4259mg/kg (4259mg/kg)		Drugs in Japan Vol. -, Pg. 119, 1995.
rat	LD50	intraperitoneal	282mg/kg (282mg/kg)		Drugs in Japan Vol. -, Pg. 119, 1995.
rat	LD50	oral	747mg/kg (747mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE KIDNEY, URETER, AND BLADDER: INCONTINENCE	Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 1, 1992.
rat	LD50	subcutaneous	2598mg/kg (2598mg/kg)		Drugs in Japan Vol. -, Pg. 119, 1995.

Specification

Ampiroxicam (CAS NO.99464-64-9), its Synonyms are Ampiroxicamum ; (+-)-4-(1-Hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester), 1,1-dioxide ; Carbonic acid, ethyl 1-((2-methyl-3-((2-pyridinylamino)carbonyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl ester, S,S-dioxide .