Reference

The in vitro activity of flomoxef compared to four other cephalosporins and imipenem

The in vitro activity of flomoxef compared to four other cephalosporins and imipenem. Shah, P. M.; Knothe, H. 99665-00-6 are also occured in this study. (Wolfgang Goethe-Univ., Frankfurt/Main W-6000, Germany). Infection (Munich), 19(Suppl. 5), S279-S283 (English) 1991. CODEN: IFTNAL. ISSN: 0300-8126. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) The antibacterial activity of the oxacephalosporin flomoxef was evaluated in comparison to cefpirome, cefuzoname, cefotaxime, ceftazidime, and imipenem against fresh clin. isolates. Flomoxef is an antibiotic with strong antibacterial activity against staphylococci, including methicillin-resistant strains and streptococci with the exception of Enterococcus faecalis and E. faecium. It is very active against gram-neg. cocci and rods, including gram-pos. and gram-neg. anaerobes. Against Pseudomonas sp. flomoxef has no activity. .

In vitro activity of flomoxef and cefazolin in combination with vancomycin

In vitro activity of flomoxef and cefazolin in combination with vancomycin. Simon, C.; Simon, Maria (Univ.-Kinderklin. 99665-00-6 and 35607-66-0 are also occured in this study. Kiel, Kiel W-2300/1, Germany). Infection (Munich), 19(Suppl. 5), S276-S278 (English) 1991. CODEN: IFTNAL. ISSN: 0300-8126. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Clin. isolates (207) were investigated for their in vitro sensitivity, by the agar diln. method, to flomoxef and cefazolin (alone and partially in combination with vancomycin). Staphylococci were also tested with other cephalosporins (cefoxitin, cefamandole, cefotaxime, cefotetan and latamoxef). Flomoxef and cefazolin always acted more vigorously on staphylococci than the other cephalosporins. Resistance of Staphylococcus aureus strains to flomoxef and cefazolin did not occur but was found in 15 and 5 of 98 S. epidermidis strains, resp. Enterococcus faecalis strains were always resistant to both drugs; S. faecium strains were only moderately sensitive. Combined testing of flomoxef or cefazolin with vancomycin showed synergism in almost all staphylococcal strains. Synergism was stronger against Staphylococcus epidermidis strains that were slightly sensitive or resistant to flomoxef and cefazolin than against highly sensitive strains. Flomoxef (or cefazolin) acted synergistically with vancomycin on E. faecalis and Streptococcus faecium, with the exception of 2 strains of E. faecalis which showed an additive effect of both drugs. .