Detail of "997-95-5"

CAS Number:
997-95-5
Name:
1-Propanamine,2-methyl-N-(2-methylpropyl)-N-nitroso-
Molecular Structure:
Formula:
C8H18 N2 O
Molecular Weight:
158.28
Synonyms:
Dipropylamine,2,2'-dimethyl-N-nitroso- (6CI,7CI,8CI); Diisobutylnitrosamine;Diisobutylnitrosoamine; N,N-Diisobutylnitrosamine; N-Nitrosodiisobutylamine;NSC 134
Density:
0.92g/cm³
Boiling Point:
237.7°Cat760mmHg
Flash Point:
97.5°C
Safety:
Mildly toxic by subcutaneous route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. Many nitrosamines compounds are carcinogens. When heated to decomposition it emits toxic fumes of NO_x. See also NITROSAMINES. Details

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Comparison of the effect of b-oxidized dipropylnitrosamine metabolites administered at equimolar doses to Syrian hamsters: Comparison of the effect of b-oxidized dipropylnitrosamine metabolites administered at equimolar doses to Syrian hamsters. Althoff, J.; Grandjean, C.; Pour, P.; Bertram, B. (Eppley Inst. Res. Cancer, Univ. Nebraska Med. Cent., Omaha, Nebr., USA). Z. Krebsforsch. Klin. Onkol., 90(2), 141-8 (English) 1977. CODEN: ZKKOBW. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) After s.c. administration of dipropylnitrosamine (NAD) [621-64-7] to Syrian hamsters, gas-liq. chromatog. anal. of the 16-h urine revealed the NAD metabolites, 2-hydroxypropyl- [39603-53-7], 2-oxopropyl- [39603-53-7], and methylpropylnitrosamine [924-46-9]. In a related series of expts., hamsters received equimolar doses of the above compds. and of N-nitrosobis(2-hydroxypropyl)amine (BHP) [53609-64-6] and 2,2'-dimethyldipropylnitrosamine (DMDPN) [997-95-5]. The metabolites as well as BHP and DMDPN had a weaker effect than did NAD on the rate and/or latency of respiratory tumors. In the respiratory tract, the segmental tumor distribution and histol. types varied according to the compds. The metabolites of NAD induced addnl. tumors in the digestive tract. These expts. do not support the concept that the b-oxidized metabolites of NAD are the proximate carcinogens of the parent compd.