100-16-3 Usage
Description
4-Nitrophenylhydrazine is a nitro substituted aryl hydrazine, characterized by its orange-red leaflet or needle-like appearance when wetted with water. It is slightly heavier than water and insoluble in water. 4-Nitrophenylhydrazine may be irritating to skin, eyes, and mucous membranes, and it can be toxic if ingested. When heated to decomposition, it emits toxic oxides of nitrogen. It is also known to be explosive and sensitive to friction in its dry state. 4-Nitrophenylhydrazine is a white to light yellow crystal powder and is defined as a member of the class of phenylhydrazines that is substituted at the 4-position by a nitro group.
Uses
1. Analytical Chemistry:
4-Nitrophenylhydrazine is used as an analytical reagent for the detection and identification of aldehydes and ketones. Its chemical properties allow it to react with these compounds, providing a means to analyze their presence in a sample.
2. Potential Anticancer Activity:
4-Nitrophenylhydrazine has shown potential anticancer activity, making it a compound of interest for further research and development in the field of oncology. Its irritant properties may also be explored for their potential applications in cancer treatment.
3. Chemical Research:
As a member of the phenylhydrazine class, 4-Nitrophenylhydrazine can be used in various chemical research applications, including the synthesis of other compounds and the study of reaction mechanisms involving aryl hydrazines.
Reactivity Profile
4-NITROPHENYLHYDRAZINE is a powerful explosive. 4-Nitrophenylhydrazine can SELF-IGNITE in the presence of contaminants. Auto-ignition temperature may vary for 4-nitrophenylhydrazine similar to that of hydrazine which has an autoignition of as low as 74oC in contact with iron rust. Dangerous fire hazard or severe explosion can occur when exposed to heat, flame or oxidizing agents. Severe explosion may also occur by chemical reaction with alkali metals; BaO; CaO; K; Na; NH3; Cl2; chromates; CuO; Cu++ salts; F2; H2O2; iron rust; metallic oxides; PbO2;Ni; Ni(ClO4)2; HNO3; N2O; O2; liquid O2; K2Cr2O7; Na2Cr2O7; tetryl; zinc diamide; Zn(C2H5)2. Dangerous; when heated to decomposition 4-Nitrophenylhydrazine emits highly toxic nitrogen compounds; may explode by heat or chemical reaction. (Sax and Lewis, 1987) under Hydrazine p. 538-539.
Health Hazard
Some are toxic and may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.
Safety Profile
Poison by intraperitoneal route.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx. See also NITROCOMPOUNDS OF AROMATIC HYDROCARBONS
Purification Methods
Crystallise the hydrazine from EtOH. The hydrochloride has m 212o(dec) (from EtOH, also m 202-203o dec). [Beilstein 15 III 331, 15 IV 317.]
Check Digit Verification of cas no
The CAS Registry Mumber 100-16-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 100-16:
(5*1)+(4*0)+(3*0)+(2*1)+(1*6)=13
13 % 10 = 3
So 100-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N3O2/c7-8-5-1-3-6(4-2-5)9(10)11/h1-4,8H,7H2
100-16-3Relevant articles and documents
Novel chemoselective reduction of aryldiazonium fluoroborates with Zn- NiCl2·6H2O-THF
Bandgar,Uppalla
, p. 714 - 715 (1999)
Substituted aryldiazonium fluoroborates are selectively reduced to the corresponding phenylhydrazines by using Zn-NiCl2·6H2O in THF as a reducing agent.
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Murray,Bradshaw
, p. 1929 (1967)
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Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides
Yang, Chu,Zhang, Feng,Deng, Guo-Jun,Gong, Hang
, p. 181 - 190 (2019/01/10)
A base-promoted amination of aromatic halides has been developed using a limited amount of dimethylformamide (DMF) or amine as an amino source. Various aryl halides, including F, Cl, Br, and I, have been successfully aminated in good to excellent yields. Although the amination of aromatic halides with amines or DMF is usually considered as an aromatic nucleophilic substitution (SNAr) process, and the reactivity of an aromatic halide is F > Cl > Br > I, the reactivity of aromatic halides in this system was found to be I > Br a‰ F > Cl. This protocol also showed a good regioselectivity for multihalogenated aromatics. This protocol is valuable for industrial application due to the simplicity of operation, the unrestricted availability of amino sources and aromatic halides, transition metal-free conditions, no requirement for solvent, and scalability.
Oxazolidinones compound and application thereof
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Paragraph 0087;0091-0092, (2016/10/10)
The invention provides an oxazolidinones compound shown as the formula VI, or salt, an aquo-complex, or a crystal form of the oxazolidinones compound, which are pharmaceutically acceptable. The invention also provides a preparation method of the compound. In the current field of a chemical drug, activity of most compounds with changed structures becomes better, while toxicity is obviously enhanced, so that the compounds cannot be used as drugs. Compared with a compound in the prior art, the oxazolidinones compound provided in the invention has excellent anti-drug-resistance and antimicrobial activity. What is unexpected is that the oxazolidinones compound has better safety and benefits safe drug use and therapy of a patient.
