10030-78-1 Usage
General Description
6-HYDROXY-2-METHYLAMINOPURINE, also known as 6-Methylaminopurine-9-hydroxide, is a purine derivative that is often used in biochemical research as a non-specific protein kinase inhibitor. It is an analog of adenine and acts as a competitive inhibitor of various kinases, including cyclic AMP-dependent protein kinases and protein kinase C. 6-HYDROXY-2-METHYLAMINOPURINE has been found to inhibit the proliferation of leukemia and breast cancer cells, making it a potential candidate for further development as an anti-cancer agent. Additionally, 6-HYDROXY-2-METHYLAMINOPURINE has also been studied for its potential to stimulate plant growth and development, as it can act as a cytokinin, a class of plant hormones that regulate cell division and differentiation.
Check Digit Verification of cas no
The CAS Registry Mumber 10030-78-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,3 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10030-78:
(7*1)+(6*0)+(5*0)+(4*3)+(3*0)+(2*7)+(1*8)=41
41 % 10 = 1
So 10030-78-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N5O/c1-7-6-10-4-3(5(12)11-6)8-2-9-4/h2-3H,1H3,(H2,7,8,9,10,11,12)
10030-78-1Relevant articles and documents
A Convenient Synthesis of N2-Alkylated Guanines
Zhu,Qin,Liu,Luo
, p. 874 - 878 (2019)
An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.
Synthesis of N2-alkyl(aryl, dialkyl, cycloalkyl)guanines
Kochergin,Persanova,Aleksandrova,Gutorov,Korsunskii
, p. 338 - 341 (2007/10/03)
Novel N2-alkyl(aryl, dialkyl, cycloalkyl)guanines have been synthesized by treating 2-chloro-7-benzylhypoxanthine with amines and debenzylation of the N2-substituted 7-benzylguanine products by means of palladium catalyzed hydrogenat