100361-18-0

• 

• Basic information

  1. Product Name: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
  2. Synonyms: 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridin-3-Carboxylic Acid;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyl ridine carbox.acid;7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Qxoquinoline-3-CarboxylicAcid98%;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacid;7-Chloro-1-cyclopropyl-6-fluor;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-Ox;7-Chloro-1-cyclopropyl-1,4-dihydro-3-oxo-1,8-naphthyridine-3-carboxylic aci;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLRIDINE CARBOXYLIC ACID 99%
  3. CAS NO:100361-18-0
  4. Molecular Formula: C₁₂H₈ClFN₂O₃
  5. Molecular Weight: 282.65
  6. EINECS: 1312995-182-4
  7. Product Categories: Heterocycles;Intermediate;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorine series
  8. Mol File: 100361-18-0.mol
  9. Article Data: 14

• Chemical Properties

  1. Melting Point: 209-212 °C
  2. Boiling Point: 485.919 °C at 760 mmHg
  3. Flash Point: 247.675 °C
  4. Appearance: White powder
  5. Density: 1.727 g/cm³
  6. Vapor Pressure: 0mmHg at 25°C
  7. Refractive Index: 1.692
  8. Storage Temp.: Inert atmosphere,Room Temperature
  9. Solubility: N/A
  10. PKA: 5.96±0.70(Predicted)
  11. CAS DataBase Reference: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(CAS DataBase Reference)
  12. NIST Chemistry Reference: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(100361-18-0)
  13. EPA Substance Registry System: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(100361-18-0)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 100361-18-0(Hazardous Substances Data)

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100361-18-0 Suppliers

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• High quality 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid supplier in China

  Cas No: 100361-18-0

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• Simagchem Corporation
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• 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

  Cas No: 100361-18-0

• USD $ 12.0-12.0 / Gram

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• Jinan Finer Chemical Co., Ltd
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• 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID

  Cas No: 100361-18-0

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

  Cas No: 100361-18-0

• USD $ 1.2-5.0 / Kiloliter

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• Chemwill Asia Co., Ltd.
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• TIANFU-CHEM -7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

  Cas No: 100361-18-0

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• Henan Tianfu Chemical Co., Ltd.
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• Top Purity CAS 100361-18-0 with fast shipping

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• Zhuozhou Wenxi import and Export Co., Ltd
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• 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

  Cas No: 100361-18-0

• USD $ 1.0-1.0 / Kilogram

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• Henan Sinotech Import&Export Corporation
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• 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid CAS:100361-18-0

  Cas No: 100361-18-0

• USD $ 1.0-10.0 / Kilogram

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• Hebei Nengqian Chemical Import and Export Co., LTD
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• 1,8-Naphthyridine-3-carboxylicacid, 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo- 100361-18-0

  Cas No: 100361-18-0

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• Shanghai Upbio Tech Co.,Ltd
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• 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid CAS:100361-18-0

  Cas No: 100361-18-0

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• 1 Gram

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• Qingdao Beluga Import and Export Co., LTD
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100361-18-0 Usage

Chemical Properties

Off-white or light yellow powder

Uses

Different sources of media describe the Uses of 100361-18-0 differently. You can refer to the following data:
1. Gemifloxacin intermediate as antibacterial agent.
2. Gemifloxacin intermediate as antibacterial agent

Check Digit Verification of cas no

The CAS Registry Mumber 100361-18-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,3,6 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 100361-18:
(8*1)+(7*0)+(6*0)+(5*3)+(4*6)+(3*1)+(2*1)+(1*8)=60
60 % 10 = 0
So 100361-18-0 is a valid CAS Registry Number.

InChI:InChI=1/C12H8ClFN2O3/c13-10-8(14)3-6-9(17)7(12(18)19)4-16(5-1-2-5)11(6)15-10/h3-5H,1-2H2,(H,18,19)

100361-18-0 Well-known Company Product Price

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• TCI America

• (C2650)  7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid  >98.0%(HPLC)(T)

• 100361-18-0

• 1g

• 590.00CNY

• Detail

• TCI America

• (C2650)  7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid  >98.0%(HPLC)(T)

• 100361-18-0

• 5g

• 1,990.00CNY

• Detail

100361-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name	7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid

1.2 Other means of identification

Product number	-
Other names	7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100361-18-0 SDS

100361-18-0Upstream product

• 99735-36-1 4-[6-(acetylcyclopropylamino)-3-fluoro-2-pyridinyl]-1-piperazine-carboxylic acid,ethyl ester 
• 96568-06-8 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate 
• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 
• 96568-07-9 ethyl-7-chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 122-51-0 orthoformic acid triethyl ester 
• 765-30-0 Cyclopropylamine 
• 99735-42-9 1-cyclopropyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid 

100361-18-0Downstream Products

• 113533-65-6 1-cyclopropyl-6-fluoro-1,4-dihydro-7-<3-<(methylamino)methyl>-1-pyrrolidinyl>-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 1356199-43-3 7-[3-(benzylideneamino)methyl-4-(3',4'-dimethxoybenzyloxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 125290-81-5 ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,2,3,4-tetrahydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 125290-82-6 7-Chloro-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,2,3,4-tetrahydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 99735-41-8 ciprofloxacin 

100361-18-0Relevant articles and documents

Quinolone Antibacterials Containing the New 7- Side Chain: The Effects of the 1-Aminoethyl Moiety and Its Stereochemical Configurations on Potency and in Vivo Efficacy

Domagala, John M.,Hagen, Susan E.,Joannides, Themis,Kiely, John S.,Laborde, Edgardo,et al.

, p. 871 - 882 (1993)

A series of stereochemically pure 7--1,4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-3-(1-aminoe

Structure aided design of chimeric antibiotics

Karoli, Tomislav,Mamidyala, Sreeman K.,Zuegg, Johannes,Fry, Scott R.,Tee, Ernest H.L.,Bradford, Tanya A.,Madala, Praveen K.,Huang, Johnny X.,Ramu, Soumya,Butler, Mark S.,Cooper, Matthew A.

, p. 2428 - 2433 (2012/05/19)

The rise of antibiotic resistance is of great clinical concern. One approach to reducing the development of resistance is to co-administer two or more antibiotics with different modes of action. However, it can be difficult to control the distribution and

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1

Tomita, Kyoji,Tsuzuki, Yasunori,Shibamori, Koh-ichiro,Tashima, Masanori,Kajikawa, Fumie,Sato, Yuji,Kashimoto, Shigeki,Chiba, Katsumi,Hino, Katsuhiko

, p. 5564 - 5575 (2007/10/03)

In an attempt to search for clinically useful antitumor agents, we have discovered that a series of 1,7-disubstituted-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids possessed moderate cytotoxic activity. We investigated the structure-acti

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