10054-29-2Relevant articles and documents
Synthesis of Alkyl Dihydrogenphosphate by the Reaction of Alcohols and Silyl Polyphosphate
Okamoto, Yoshiki
, p. 3393 - 3394 (1985)
Alkyl dihydrogenphosphates were readily prepared by phosphorylation of alcohols with trimethylsilyl polyphosphate of polyphosphorylated silica-gel.
Alkyl and alkoxyethyl antineoplastic phospholipids
Koufaki, Maria,Polychroniou, Vanessa,Calogeropoulou, Theodora,Tsotinis, Andrew,Drees, Markus,Fiebig, Heiner H.,LeClerc, Sophie,Hendriks, Hans R.,Makriyannis, Alexandros
, p. 2609 - 2614 (1996)
Two series of phosphodiester ether lipid analogs with (N- methylmorpholino)ethyl or (N-methylpiperidino)ethyl polar head groups and long aliphatic or alkoxyethyl chains in the nonpolar portion of the molecule were synthesized as potential antineoplastic agents. The cytotoxic activity of these compounds (9-19) was evaluated in vitro against a panel of six human tumor xenografts and in two biochemical, mechanism-based screens (cdc2 kinase and cdc25 phosphatase). Analogs 13, 14, 17, and 19 showed activity in the in vitro tests. Specifically, 14 and 17 were more active than the reference compound hexadecylphosphocholine (Miltefosine, He-PC) while 13 and 19 possessed activity similar to that of the control. Of the analogs tested the one with the highest potency and least toxicity (17) has an N- methylpiperidino head group and a C16 alkyl chain. In the mechanism-based tests 11 showed weak inhibitory activity in the cdc25 phosphatase screen.
Phospholipid-induced aggregation and anthracene excimer formation
Chen, Kuan-Hung,Yang, Jye-Shane,Hwang, Chung-Yu,Fang, Jim-Min
supporting information; experimental part, p. 4401 - 4404 (2009/05/27)
(Chemical Equation) The zinc complex of anthryl bis(dipicolylamine) (1) aggregates upon binding with long-chain aliphatic phosphates and displays anthracene excimer fluorescence, which provides a new strategy toward detection of the biologically important lysophosphatidic acid in aqueous solution.