10066-18-9Relevant articles and documents
Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies
Kumar, Niggula Praveen,Sharma, Pankaj,Kumari, S. Sujana,Brahma, Umarani,Nekkanti, Shalini,Shankaraiah, Nagula,Kamal, Ahmed
, p. 128 - 140 (2017)
A series of new phenanthrene-9-benzimidazole conjugates has been synthesized by condensing phenanthrene aldehydes with various substituted o-phenylenediamines. The title compounds were evaluated for their in vitro cytotoxic potential against various human
Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents
Goud, Nerella Sridhar,Ghouse, S. Mahammad,Vishnu, Jatoth,Komal,Talla, Venu,Alvala, Ravi,Pranay, Jakkula,Kumar, Janish,Qureshi, Insaf A.,Alvala, Mallika
, (2019/06/13)
In our pursuit to develop novel non-carbohydrate small molecule Galectin-1 Inhibitors, we have designed a series of 1-benzyl-1H-benzimidazole derivatives and demonstrated their anticancer activity. The compound 6g, 4-(1-benzyl-5-chloro-1H-benzo[d]imidazol
Construction of Druglike 2-Amido Benzo[ d]imidazole Analogues via Desulfurative Cyclization of Thiourea Intermediate Resin on Solid-Phase
Ryu, Hyun-Jeong,Yang, Seung-Ju,Lee, Gee-Hyung,Gong, Young-Dae
supporting information, p. 282 - 291 (2018/05/24)
A 2-amido benzo[d]imidazole library has been constructed by solid-phase synthesis. The key step of this solid-phase synthesis involves the preparation of polymer-bound 2-amino benzo[d]imidazole resin through desulfurative cyclization of thiourea resin using 2-chloro-1,3-dimethylimidazolinium chloride and N,N-diisopropylethylamine in dichloromethane (DCM), and the resin is then functionalized by acylation at the 2-amine position to afford 2-amidobenzo[d]imidazole resin. In the case of 2-amidobenzo[d]imidazole resin having a p-I or m-NO2, the resin was further functionalized by Suzuki/Sonogashira-coupling (p-I) and reduction to the primary amine (m-NO2) followed by acylation. Finally, the functionalized 2-amido-benzo[d]imidazole resin was cleaved from the polymer support by treatment with a cocktail of trifluoroacetic acid and DCM. As a result, we obtained 2-amidobenzo[d]imidazole analogues in high yield and good purities.