100905-89-3Relevant articles and documents
A convergent strategy for the pamamycin macrodiolides: Total synthesis of pamamycin-607, pamamycin-593, and pamamycin-621D precursors
Lanners, Steve,Norouzi-Arasi, Hassan,Salom-Roig, Xavier J.,Hanquet, Gilles
, p. 7086 - 7089 (2007)
A convergent total synthesis of pamamycin-607 (1), isolated from Streptomyces alboniger, was achieved by an E-Z isomerization of a tetrahydrofuran alkylidene and a regio- and diastereoselective solvent-dependent cyclo-C6H11BCl/Etsub
Stereoselective synthesis of pamamycin-607
Jeong, Eun Jeong,Kang, Eun Joo,Sung, Lee Taek,Hong, Sung Kil,Lee, Eun
, p. 14655 - 14662 (2007/10/03)
A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.
Total synthesis of pamamycin-607 [17]
Lee,Eun Jeong Jeong,Eun Joo Kang,Lee Taek Sung,Sung Kil Hong
, p. 10131 - 10132 (2007/10/03)
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