101257-38-9 Usage
Description
THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE is an organic compound characterized by its unique structure that features a thiazole ring and a carboxylic acid group, coupled with a hydrazide functional group. It is recognized for its significant role as a precursor in the pharmaceutical industry, particularly for the development of drugs with antibacterial and antifungal properties. Its versatility as a building block in the synthesis of other organic compounds and its potential applications in medicinal and agricultural chemistry make it an important starting material for the production of thiazole derivatives.
Uses
Used in Pharmaceutical Industry:
THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE is used as a precursor for the development of pharmaceuticals, specifically for those with antibacterial and antifungal properties. Its structural features allow for the creation of compounds that can effectively target and combat bacterial and fungal infections.
Used in Organic Synthesis:
In the field of organic synthesis, THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE is utilized as a building block for the synthesis of a variety of organic compounds. Its unique functional groups enable the formation of diverse chemical entities with potential applications in various industries.
Used in Medicinal Chemistry:
THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE is employed as a starting material for the production of thiazole derivatives, which have wide-ranging applications in medicinal chemistry. These derivatives are valuable for their potential therapeutic properties and are being studied for their use in treating various diseases and conditions.
Used in Agricultural Chemistry:
THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE also finds use in agricultural chemistry, where it serves as a starting material for the synthesis of thiazole-based agrochemicals. These agrochemicals can be used for the control of pests and diseases in crops, contributing to increased agricultural productivity.
Used in the Treatment of Infectious Diseases:
THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE has been studied for its potential use in the treatment of tuberculosis and other infectious diseases. Its ability to inhibit certain enzymes and metabolic pathways in bacteria and fungi makes it a promising candidate for the development of new antimicrobial agents.
Check Digit Verification of cas no
The CAS Registry Mumber 101257-38-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,2,5 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 101257-38:
(8*1)+(7*0)+(6*1)+(5*2)+(4*5)+(3*7)+(2*3)+(1*8)=79
79 % 10 = 9
So 101257-38-9 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N3OS/c5-7-4(8)3-1-9-2-6-3/h1-2H,5H2,(H,7,8)
101257-38-9Relevant articles and documents
Extension of Azine-Triazole Synthesis to Azole-Triazoles Reduces Ligand Field, Leading to Spin Crossover in Tris-L Fe(II)
Brooker, Sally,Singh, Sandhya
, (2020)
The first examples of azole-Triazole Rat ligands, bidentate L4NMeIm(3-(1-methyl-1H-imidazol-4-yl)-5-phenyl-4-(p-Tolyl)-4H-1,2,4-Triazole) and L4SIm (4-(5-phenyl-4-(p-Tolyl)-4H-1,2,4-Triazol-3-yl)thiazole), have been prepared, by extension of the general synthesis used to access many examples of azine-Triazoles. The tris-L FeII complexes of the azine-Triazoles are consistently low spin (LS). As intended, these new azole-Triazole ligands provide lower field strengths, resulting in high-spin (HS) [FeII(L4NMeIm)3](BF4)2 (1·4H2O) and spin crossover (SCO) active [FeII(L4SIm)3](BF4)2 (2·0.5H2O). Single-crystal structure determinations revealed that at 100 K 1·solvents is HS whereas 2·solvents is LS. Solid-state variable temperature magnetic studies of air-dried crystals showed that the methylimidazole-Triazole complex 1·4H2O remains HS while the thiazole-Triazole complex 2·0.5H2O undergoes a two-step gradual SCO (T1/2 approximately 275 and 350 K). Variable-Temperature Evans method NMR studies of 2, in five different solvents (CD3NO2, CD3CN, CD3COCD3, CD2Cl2, and CDCl3) gave T1/2 values in a relatively narrow range, 214-259 K. These T1/2 values did not correlate with the solvent polarity index P′ (R2 = 0.25) but did correlate with the solvent basicity parameter SB (R2 = 0.90). Variable-Temperature UV-vis studies on a golden yellow CH3CN solution of 2, with monitoring of the d-d transition at 530 nm (? = 39 L mol-1 cm-1 at 293 K) while the solution was heated from 253 to 303 K, showed that the high-spin fraction increased from 0.51 to 0.77. Cyclic voltammetry studies in CH3CN revealed a Fe(III)/Fe(II) redox process that was reversible for 1 and irreversible for 2, with significant tuning of the Epa value: The methylimidazole-Triazole complex 1 is significantly easier to oxidize (0.46 V) than the thiazole-Triazole complex 2 (0.68 V; both vs 0.01 M Ag/AgNO3).
