101396-91-2Relevant articles and documents
L-carnitine. Novel synthesis and determination of the optical purity
Voeffray,Perlberger,Tenud,Gosteli
, p. 2058 - 2064 (1987)
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Enantiomer separation of rac-2,2′-dihydroxy-1,1′-binaphthyl (BNO) by inclusion complexation with racemic or achiral ammonium salts and a novel transformation of a 1:1:1 racemic complex of BNO, Me4N +·Cl- and MeOH into a conglomerate complex in the solid state
Yoshizawa, Kazuhiro,Toyota, Shinji,Toda, Fumio
, p. 7767 - 7774 (2004)
The complete simultaneous and mutual enantiomer resolution of 2,2′-dihydroxy-1,1′-binaphthyl (BNO) and N-(3-chloro-2- hydroxypropyl)-N,N,N-trimethylammonium chloride, Me3N +CH2CH(OH)CH2Cl·Cl- into their enantiomers by inclusion complexation between their racemates in EtOH in the presence of a chiral seed crystal is reported. The enantiomer resolution of the rac-BNO was also accomplished easily by inclusion complexation with achiral ammonium salts, N-(2-hydroxyethyl)-N,N,N-trimethylammonium chloride, Me 3N+CH2CH2OH·Cl- and tetramethylammonium chloride, Me4N+·Cl -. Inclusion complexation of the rac-BNO with Me3N + CH2CH2OH·Cl- gave only a 1:1 conglomerate inclusion complex but not a racemic complex. Recrystallization of the rac-BNO and an equimolar amount of Me4N+· Cl- from MeOH (7 ml) and MeOH (15 ml) gave a 1:1:1 racemic complex, BNO·Me4N+·Cl-·MeOH and a 1:1 conglomerate complex, BNO·Me4N+·Cl -, respectively. Novel transformation of the former racemate into the latter conglomerate occurred by heating or by exposure to MeOH vapor in the solid state.
Synthesis and physicochemical properties of low-substituted cationic ethers of starch
Butrim,Butrim,Bil'dyukevich,Yurkshtovich,Kaputskii
, p. 2026 - 2032 (2008)
The kinetics of the formation of cationic starch ethers under the action of 3-chloro-2-hydroxypropyltrimethylammonium chloride is studied in relation to the reactant molar ratio, temperature, and concentration of the starch suspension. Comparative data on
Synthetic method of biquaternary ammonium salt intermediate
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Paragraph 0015-0024, (2020/10/14)
The invention provides a synthetic method of a biquaternary ammonium salt intermediate. The synthetic method comprises the following step: in a water phase, reacting 1,3-dichloropropanol with trimethylamine at a low temperature to generate the biquaternary ammonium salt intermediate 3-chloro-2-hydroxypropyl trimethyl ammonium chloride. According to the invention, 1,3-dichloropropanol is used as aconnecting group, and the industrial chain and application of 1,3-dichloropropanol are expanded based on a 1,3-dichloropropanol production line; the reaction is performed in a water phase, so the useof an organic solvent is avoided, and safety and environmental protection are realized; and the method adopts a low-temperature reaction, and is safe and energy-saving.
Preparation method of levocarnitine
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Paragraph 0026; 0027; 0028; 0029, (2017/08/29)
The invention provides a preparation method of levocarnitine. The preparation method comprises the following steps: taking epoxy chloropropane as a starting material, then carrying out amination, cyaniding and carrying out ester exchange under the action of lipase CALB to obtain corresponding chiral ester, then carrying out alkaline hydrolysis and acidification, and then removing chlorine ions under the action of strongly alkaline resin, so that the levocarnitine finished product is obtained. In the invention, acid resin is used in an ester exchange process, and recemization can be realized, so that yield and optical purity of the levocarnitine are improved.
