101760-45-6 Usage
General Description
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-prop-2-ynyl-amino]benzoyl]amino]pentanedioic acid, also known as Aladast, is a chemical compound that belongs to the class of drugs known as antineoplastics. It is used in the treatment of certain types of leukemia and malignant lymphomas. Aladast works by inhibiting the growth and spread of cancer cells in the body. It is typically administered intravenously and is only available with a prescription from a healthcare provider. As with any medication, Aladast may have potential side effects and interactions with other drugs, so it should be taken under the supervision of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 101760-45-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,7,6 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 101760-45:
(8*1)+(7*0)+(6*1)+(5*7)+(4*6)+(3*0)+(2*4)+(1*5)=86
86 % 10 = 6
So 101760-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H21N7O6/c1-2-9-29(11-13-10-24-18-17(25-13)20(33)28-22(23)27-18)14-5-3-12(4-6-14)19(32)26-15(21(34)35)7-8-16(30)31/h1,3-6,10,15H,7-9,11H2,(H,26,32)(H,30,31)(H,34,35)(H3,23,24,27,28,33)/t15-/m0/s1
101760-45-6Relevant articles and documents
Synthesis of 10-Propargylfolic Acid from 2-Amino-6-(bromomethyl)-4(1H)-pteridinone
Piper, James R.,McCaleb, George S.,Montgomery, John A.
, p. 279 - 282 (2007/10/02)
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide (1) is readily converted to 2-amino-6-(bromomethyl)-4(1H)-pteridinone hydrobromide (2) by treatment with 48percent hydrobromic acid.Compound 2 is of interest for direct attachment of the (2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl group to appropriate side-chain precursors of analogues of folic acid, particularly those bearing functional groups incompatible with conditions required for hydrolytic deamination of the corresponding 2,4-diaminopteridine analogues.An example of the use of 2 in this connection is demonstrated through synthesis of 10-propargylfolic acid.
