10184-51-7Relevant articles and documents
Reactions of 9-substituted 1-aminoadenines with nucleophiles and syntheses of 3-substituted 3H-imidazo[4,5-e][1,2,4]triazolo[1,5-c][1,2,3]triazines
Asano,Itano,Yamagata,Kohda
, p. 1453 - 1465 (1994)
Reactions of 1-aminoadenines (2) with NH2OH gave adenine 1-oxides (6). Alkaline treatment of 2 afforded 5-amino-4-(1,2,4-triazol-3-yl)imidazoles (3), which were converted to 3H-imidazo[4,5-e][1,2,4]triazolo[1,5- c][1,2,3]triazines (5), aza analogues of 3H-[1,2,4]triazolo[3,2-i]purines (4), by treatment with NaNO2.
A NEW SYNTHETIC ROUTE TO 2-DEUTERIOADENINES SUBSTITUTED OR UNSUBSTITUTED AT THE 9-POSITION
Fujii, Tozo,Saito, Tohru,Hayashibara, Hiromi,Kumazawa, Yukinari,Nakajima, Satoshi
, p. 2449 - 2454 (2007/10/02)
9-alkyl-2-deuterioadenines (VIII b-d) , adenosine-2-d (VIIIe), and 2'-deoxyadenosine-2-d (VIIIf) were synthesized from the 9-substituted adenines Ib-f through cyclization of the monocyclic intermediates VIb-f with formic acid-d2 or 1-(formyl-d)-2-(1H)-pyridone.Hydrolysis of VIIIe, prepared through this synthetic route, with 0.5 N aqueous HCl ( reflux, 2h) gave adenine-2-d (VIIIa) in 77percent yield.Unambiguous assigments of the purine ring protons in the NMR spectra of the unlabeled adenines Ia-f have been made by comparison with those of the labeled adenines VIIIa-f.
