102153-63-9Relevant articles and documents
Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors
Imaeda, Yasuhiro,Miyawaki, Toshio,Sakamoto, Hiroki,Itoh, Fumio,Konishi, Noriko,Hiroe, Katsuhiko,Kawamura, Masaki,Tanaka, Toshimasa,Kubo, Keiji
, p. 2243 - 2260 (2008/12/20)
Factor Xa (FXa) is a trypsin-like serine protease involved in the coagulation cascade and has received great interest as a potential target for the development of new antithrombotic agents. Most of amidine-type FXa inhibitors reported have been found to s
Substituted heterocyclic amides
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, (2008/06/13)
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermedia
Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c] pyridine derivatives
Haginoya, Noriyasu,Kobayashi, Syozo,Komoriya, Satoshi,Hirokawa, Yumiko,Furugori, Taketoshi,Nagahara, Takayasu
, p. 2935 - 2939 (2007/10/03)
In our investigation of factor Xa inhibitors, a series of 1-(6-chloronaphthalen-2-yl)sulfonyl-4-(4,5,6,7-tetrahydrothiazolo[5,4-c] pyridine-2-carbonyl)piperazines 3a-i were synthesized. In vitro inhibitory activities of the compounds against factor Xa and coagulation are summarized. Among the compounds, 3c and 3d, possessing a carbamoyl or N-methylcarbamoyl moiety, showed potent inhibitory activities when administered orally to rats.