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1022-31-7

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1022-31-7 Usage

Uses

N''-Formylkynurenine is a photooxidation product of Tryptophan (T947200), and is also used as a photosensitizer of near-ultraviolet radiation by generating singlet oxygen and superoxide.

Check Digit Verification of cas no

The CAS Registry Mumber 1022-31-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,2 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1022-31:
(6*1)+(5*0)+(4*2)+(3*2)+(2*3)+(1*1)=27
27 % 10 = 7
So 1022-31-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1

1022-31-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N-formylkynurenine

1.2 Other means of identification

Product number -
Other names 2-amino-4-(2-formamidophenyl)-4-oxo-butanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1022-31-7 SDS

1022-31-7Downstream Products

1022-31-7Relevant articles and documents

A new mechanism of the photochemical oxidation of tryptophan sensitised with the uranyl ion

Ostakhov, Sergey S.,Kazakov, Valerii P.,Osina, Irina O.

, p. 113 - 114 (2009)

It has been found that tryptophan oxidation sensitised with the uranyl ion occurs as a chain reaction of Trp+ cation radicals with O2.

-

Saito,I.,Matsuura,T.,Inoue,K.

, p. 188 (1981)

-

Dye-sensitized Photo-oxygenation of Tryptophan to give N'-Formylkynurenine

Nakagawa, Masako,Kato, Shiro,Nakano, Kumiko,Hino, Tohru

, p. 855 - 856 (1981)

Exclusive conversion of the tricyclic hydroperoxide (1) into N'-formylkynurenine (2) has been found to occur in Na2CO3-AcOH (pH 7) and the methylene blue-sensitized photo-oxygenation of tryptophan in the same system has given N'-formylkynurenine as the sole product, in contrast with the reaction in water, which gave compound (1).

Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine

Tomek, Petr,Palmer, Brian D.,Kendall, Jackie D.,Flanagan, Jack U.,Ching, Lai-Ming

, p. 1772 - 1780 (2015)

Background Tryptophan catabolism along the kynurenine pathway is associated with a number of pathologies including cataract formation and cancer. Whilst the chemical reactions of kynurenine are well studied, less is known about the reactivity of its precu

Nitrobenzofurazan derivatives of N′-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1

Paul, Saurav,Roy, Ashalata,Deka, Suman Jyoti,Panda, Subhankar,Trivedi, Vishal,Manna, Debasis

, p. 364 - 375 (2016/06/13)

Tryptophan metabolism through the kynurenine pathway is considered as a crucial mechanism in immune tolerance. Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in tryptophan catabolism in the immune system and it is also considered as an important therapeutic target for the treatment of cancer and other diseases that are linked with kynurenine pathway. In this study, a series of nitrobenzofurazan derivatives of N′-hydroxybenzimidamides (1) and N′-hydroxy-2-phenylacetimidamides (2) were synthesized and their inhibitory activities against human IDO1 enzyme were tested using in-vitro and cellular enzyme activity assay. The optimization leads to the identification of potent compounds, 1d, 2i and 2k (IC50 = 39-80 nM), which are either competitive or uncompetitive inhibitors of IDO1 enzyme. These compounds also showed IDO1 inhibition potencies in the nanomolar range (IC50 = 50-71 nM) in MDA-MB-231 cells with no/negligible amount of cytotoxicity. The stronger selectivity of the potent compounds for IDO1 enzyme over tryptophan 2,3-dioxygenase (TDO) enzyme (312-1593-fold) also makes them very attractive for further immunotherapeutic applications.

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