102365-46-8

• 

• Basic information

  1. Product Name: [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI)
  2. Synonyms: [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI)
  3. CAS NO:102365-46-8
  4. Molecular Formula: C4H5N7
  5. Molecular Weight: 0
  6. EINECS: N/A
  7. Product Categories: TRIAZINE
  8. Mol File: 102365-46-8.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI)(CAS DataBase Reference)
  10. NIST Chemistry Reference: [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI)(102365-46-8)
  11. EPA Substance Registry System: [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI)(102365-46-8)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 102365-46-8(Hazardous Substances Data)

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• Downstream Products
• Article

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• 1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE-5,7-DIAMINE

  Cas No: 102365-46-8

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• Hangzhou Fandachem Co.,Ltd
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• AGN 191765

  Cas No: 102365-46-8

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• Richest Group Ltd.
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• [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine

  Cas No: 102365-46-8

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• Shanghai united Scientific Co.,Ltd.
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102365-46-8 Usage

General Description

[1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine (9CI) is a chemical compound with the molecular formula C4H4N8. It belongs to the class of heterocyclic compounds, specifically triazinodiazines. [1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI) is an organic molecule that consists of a triazolo[1,5-a][1,3,5]triazine skeleton with two amino groups attached at positions 5 and 7. It has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceuticals. Additionally, it may also have uses in other industries such as agriculture and material science. The compound's specific properties, applications, and potential health and environmental impacts would require further research and study.

Check Digit Verification of cas no

The CAS Registry Mumber 102365-46-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,3,6 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 102365-46:
(8*1)+(7*0)+(6*2)+(5*3)+(4*6)+(3*5)+(2*4)+(1*6)=88
88 % 10 = 8
So 102365-46-8 is a valid CAS Registry Number.

102365-46-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

1.2 Other means of identification

Product number	-
Other names	[1,2,4]Triazolo[1,5-a][1,3,5]triazine-5,7-diamine(9CI)

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:102365-46-8 SDS

102365-46-8Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 61-82-5 3-amino-1,2,4-triazole 

102365-46-8Downstream Products

102365-46-8Relevant articles and documents

A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

Redenti, Sara,Marcovich, Irene,De Vita, Teresa,Pérez, Concepción,De Zorzi, Rita,Demitri, Nicola,Perez, Daniel I.,Bottegoni, Giovanni,Bisignano, Paola,Bissaro, Maicol,Moro, Stefano,Martinez, Ana,Storici, Paola,Spalluto, Giampiero,Cavalli, Andrea,Federico, Stephanie

supporting information, p. 310 - 314 (2019/01/24)

Glycogen synthase kinase 3β (GSK-3β) and casein kinase 1δ (CK-1δ) are emerging targets for the treatment of neuroinflammatory disorders, including Parkinson's disease. An inhibitor able to target these two kinases was developed by docking-based design. Compound 12, 3-(7-amino-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl)-2-cyanoacrylamide, showed combined inhibitory activity against GSK-3β and CK-1δ [IC50(GSK-3β)=0.17 μm; IC50(CK-1δ)=0.68 μm]. In particular, classical ATP competition was observed against CK-1δ, and a co-crystal of compound 12 inside GSK-3β confirmed a covalent interaction between the cyanoacrylamide warhead and Cys199, which could help in the development of more potent covalent inhibitors of GSK-3β. Preliminary studies on in vitro models of Parkinson's disease revealed that compound 12 is not cytotoxic and shows neuroprotective activity. These results encourage further investigations to validate GSK-3β/CK-1δ inhibition as a possible new strategy to treat neuroinflammatory/degenerative diseases.

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