103201-78-1 Usage
General Description
Trans-4-Cyclohexyl-L-proline, also known as Tx-4C-L-PRO, is a synthetic amino acid that is often used in peptide synthesis. Its structure consists of a proline residue, essential for protein formation, with a cyclohexyl group attached. This non-standard amino acid is often used in medicinal chemistry research due to its unique properties that can influence peptide conformation and stability. trans-4-Cyclohexyl-L-proline, with its stereochemically rigid, complex structure, attracts interest from researchers studying protein folding, conformation, and biological activity. Despite its synthetic nature, it's generally well-tolerated in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 103201-78-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,0 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 103201-78:
(8*1)+(7*0)+(6*3)+(5*2)+(4*0)+(3*1)+(2*7)+(1*8)=61
61 % 10 = 1
So 103201-78-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)/t9-,10+/m1/s1
103201-78-1Relevant articles and documents
Preparation methods of antihypertensive Fosinopril sodium and key intermediate thereof
-
, (2017/12/14)
The invention relates to preparation methods of an antihypertensive Fosinopril sodium and a key intermediate thereof trans-4-phenyl-L-proline suitable for industrial production. Synthesis of the key intermediate trans-4-phenyl-L-proline has high chiral selectivity, and the method is simple and easy to operate.
A convenient method for synthesis of trans-4-cyclohexyl-L-proline
Chen, Xiao,Du, Da-Ming,Hua, Wen-Ting
, p. 43 - 46 (2007/10/03)
A convenient method for the synthesis of the fosinopril precursor, trans-4-cyclohexyl-L-proline 1, has been developed. A highly stereoselective alkylation of N-benzyl-pyroglutamic acid 2 with 3-bromocyclohexene at -10°C and subsequent hydrogenolysis affor
