103460-90-8 Usage
General Description
1-Cyclopropyl-7-(3,5-dimethylpiperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, also known as Norfloxacin, is a synthetic chemical compound classified under the larger group of fluoroquinolone antibiotics. This organic compound, featuring multiple functional groups like carboxylic acid, piperazine, and quinolone, is known to exhibit antibacterial properties, mainly against gram-negative bacteria. The mechanism of action involves the inhibition of bacterial DNA gyrase, an essential enzyme necessary for replication, transcription, and repair of bacterial DNA. With a chemical formula of C16H18F2N3O3, the chemicals exhibits physical properties such as crystalline form, white or light yellow color, and a molecular weight of 319.334 g/mol. Commonly found in medications like Noroxin, this chemical compound is used in treating urinary tract infections, gonorrhea, and other bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 103460-90-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,6 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 103460-90:
(8*1)+(7*0)+(6*3)+(5*4)+(4*6)+(3*0)+(2*9)+(1*0)=88
88 % 10 = 8
So 103460-90-8 is a valid CAS Registry Number.
103460-90-8Relevant articles and documents
Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship
Domagala,Bridges,Culbertson,Gambino,Hagen,Karrick,Porter,Sanchez,Sesnie,Spense,Szotek,Wemple
, p. 1142 - 1154 (2007/10/02)
A series of 5-amino- and 5-hydroxyquinolone antibacterials substituted at C7 with a select group of common piperazinyl and 3-aminopyrrolidinyl side chains was prepared. These 5-substituted derivatives were compared to the analogous 5-hydrogen compounds for antiinfective activity by using DNA gyrase inhibition, minimum inhibitory concentrations against a variety of bacteria, and in vivo efficacy in the mouse infection model. The influence on the structure-activity relationships of varied substituents at C8 (H, F, Cl) and N1 (ethyl, cyclopropyl, difluorophenyl) was also studied. The results showed that several of the structure-activity conclusions regarding side-chain bulk at C7, the effect of halogen at C8, and the effect of the C5-amino group were greatly influenced by the choice of the N1-substituent. Several outstanding broad spectrum quinolones were identified in this work. In particular, the spectrum and potency of the 7-piperazinyl quinolones could be greatly enhanced by the judicious choice of C5-, C8-, and N1-substitutents.
