10357-07-0 Usage
Description
N4-Benzoyl-5-fluorocytosine, also known as 4-Benzoyl-5-fluorocytosine, is a synthetic compound derived from cytosine with potential antineoplastic and antiviral activities. It features a fluorine atom at position 5 and a benzoyl group linked to the amino group at position 4. This unique structure endows it with the ability to interfere with DNA replication and protein synthesis in cancer cells and viruses, positioning it as a promising candidate for cancer therapy and antiviral treatment.
Uses
Used in Cancer Therapy:
N4-Benzoyl-5-fluorocytosine is used as an anticancer agent for its potential to disrupt DNA replication and protein synthesis in cancer cells. It has been investigated for its efficacy against various types of cancer, with research highlighting its promising anticancer activity.
Used in Antiviral Treatment:
In the field of antiviral treatment, N4-Benzoyl-5-fluorocytosine is utilized for its ability to interfere with viral replication processes. Its antiviral properties make it a potential candidate for the development of treatments against viral infections.
Used in Pharmaceutical Research and Development:
N4-Benzoyl-5-fluorocytosine is used as a subject of research in pharmaceutical development, with ongoing studies aimed at understanding its mechanism of action and optimizing its potential for clinical use. This includes exploring its synergistic effects with other drugs and developing drug delivery systems to enhance its bioavailability and therapeutic outcomes.
Used in Drug Synthesis:
As a derivative of cytosine, N4-Benzoyl-5-fluorocytosine is also used in the synthesis of other pharmaceutical compounds, leveraging its unique chemical properties to create new molecules with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 10357-07-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,5 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10357-07:
(7*1)+(6*0)+(5*3)+(4*5)+(3*7)+(2*0)+(1*7)=70
70 % 10 = 0
So 10357-07-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H8FN3O2/c12-8-6-13-11(17)15-9(8)14-10(16)7-4-2-1-3-5-7/h1-6H,(H2,13,14,15,16,17)
10357-07-0Relevant articles and documents
N -Glycosylation with sulfoxide donors for the synthesis of peptidonucleosides
Beau, Jean-Marie,Beretta, Margaux,Dr?ge, Thomas,Es-Sayed, Mazen,Nicolas, Lionel,Norsikian, Stéphanie,Rouchaud, Emilie,Vors, Jean-Pierre
supporting information, p. 4285 - 4291 (2021/05/31)
The synthesis of glycopyranosyl nucleosides modified in the sugar moiety has been less frequently explored, notably because of the lack of a reliable method to glycosylate pyrimidine bases. Herein we report a solution in the context of the synthesis of peptidonucleosides. They were obtained after glycosylation of different pyrimidine nucleobases with glucopyranosyl donors carrying an azide group at the C4 position. A methodological study involving different anomeric leaving groups (acetate, phenylsulfoxide and ortho-hexynylbenzoate) showed that a sulfoxide donor in combination with trimethylsilyl triflate as the promoter led to the best yields.
