104065-67-0Relevant articles and documents
Magnesium(ii)-catalyzed asymmetric hetero-Diels-Alder reaction of Brassard's dienes with isatins
Zheng, Jianfeng,Lin, Lili,Kuang, Yulong,Zhao, Jiannan,Liu, Xiaohua,Feng, Xiaoming
supporting information, p. 994 - 996 (2014/01/06)
The first catalytic asymmetric hetero-Diels-Alder reaction of Brassard's dienes with isatins was realized using Mg(ii)/N,N′-dioxide complexes as catalysts, affording the corresponding chiral spirolactones bearing tetrasubstituted centers in up to 99% yield with up to 99% ee and >99:1 dr within 3 hours. In the mechanism, based on the operando IR experiments, a predominant Diels-Alder pathway was found in the reaction. A possible transition state model was also proposed. This journal is