104098-48-8 Usage
Uses
Different sources of media describe the Uses of 104098-48-8 differently. You can refer to the following data:
1. Imazapic is registered throughout the world for use
in peanuts, rangeland, sugarcane, and imidazolinoneresistant
canola (12). A nonionic surfactant or oil adjuvant
is required for maximum activity.
2. Imazapic can be used in analytical and biological studies of residue analysis and determination of imidazolinone herbicides in sunflower and soil by GC-MS.
Pharmacology
Imazapic kills plants by inhibiting acetolactate synthase
(ALS) (I50 = 1 μM), which is the first common enzyme in
the biosynthesis of the branched chain amino acids, valine,
leucine, and isoleucine. Imazapic is rapidly absorbed
through the leaves of plants. Once it enters the plant,
imazapic translocates to the growing points and growth
ceases within 1 day after herbicide application followed by
chlorosis and then necrosis of the growing points. Total
plant death will occur within 2 to 3 weeks after treatment.
Environmental Fate
Imazapic is weakly to moderately adsorbed on sandy loam
and silt loam soils. The Freundlich adsorption coefficient
ranges from 0.17 to 2.99, (12). Because imazapic is a weak
acid and exists in different ionic states, soil pH has an effect
on soil binding properties. The anionic form predominates
at soil pH as low as 5.5, and this form binds weakly to soil. The neutral or molecular form is important at
soil pH from 4 to 6.5. This form binds to soil organic
matter and clay. The cationic form is important at pH
less than 4. Because the soil is a heterogeneous mixture of acid and base chemical groups, there may be sites within
a particular soil that are 2 to 3 pH units higher or lower
than the average pH. The cationic form will bind tightly to
the lower pH components. Because of these interactions,
small decreases in pH below 6 will result in large increases
in binding. The half-life of imazapic in the soil is 106 d.
Imazapic remains in the top 30 cm of the soil with low
leaching potential. The degradation route of imazapic in
the soil has not been determined.
Metabolism
Plant Metabolism. The selectivity of imazapic is due to
differential rates and routes of metabolism in tolerant
crops versus susceptible weeds(10). Imazapic
has excellent selectivity in peanuts, but is not selective in
soybeans. The difference in the tolerance of these two
legumes is due to the different routes of metabolism
of imazapic in the two crops. The primary metabolite
in soybeans is an imidazopyrrolo-pyridine derivative,
whereas in peanuts, the primary metabolite is the
glucose conjugate of hydroxy-imazapic. Although the
imidazopyrrolo-pyridine derivative formed in soybean is
immobile and is not an inhibitor of acetolactate synthase,
the rate of degradation of imazapic in soybeans is not rapid
enough for selectivity (10). In imidazolinone-resistant
crops, the primary mechanism of selectivity is due to
an altered acetolactate synthase that is not inhibited by
the imazapic (11).
Animal Metabolism (12). Metabolism studies in the rat
showed that imazapic is rapidly excreted in the urine.
There was no accumulation of imazapic or any of its
derivatives in the liver, kidney, muscle, fat, or blood.
Toxicity evaluation
Imazapic has shown no mutagenic or genotoxic activity in
the Ames assay, mammalian cell gene mutation assay, in
vitro chromosome aberration assay, in vitro unscheduled
DNA synthesis (URS) assay, or the in vivo dominant lethal
assay inmale rats. The acute toxicity and effects on wildlife
and soil microflora of imazapic are shown in Table 6. This
herbicide also has a low potential for bioaccumulation
in fish.
Check Digit Verification of cas no
The CAS Registry Mumber 104098-48-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,0,9 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104098-48:
(8*1)+(7*0)+(6*4)+(5*0)+(4*9)+(3*8)+(2*4)+(1*8)=108
108 % 10 = 8
So 104098-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N3O3.H3N/c1-7(2)14(4)13(20)16-11(17-14)10-9(12(18)19)5-8(3)6-15-10;/h5-7H,1-4H3,(H,18,19)(H,16,17,20);1H3
104098-48-8Relevant articles and documents
Synthetic method of imazameth
-
, (2021/01/11)
The invention relates to a synthetic method of imazameth, wherein the synthetic method comprises the following steps: reacting 5-methylpyridine-2,3-dicarboxylic acid serving as a raw material with acetic anhydride to generate 5-methylpyridine-2,3-dicarboxylic anhydride; and under a low-temperature condition, continuing to react with alcohol to generate a compound represented by a structural formula (I), carrying out ring closing reaction on the compound and 2-amino-2,3-dimethylbutyramide under an alkaline condition to generate imazameth sodium salt, extracting to regulate the pH value, and thus obtaining an imazameth product. The method has the advantage that a new method for obtaining imazameth is provided. The method is high in reaction speed, extremely high in product purity, high in yield, mild in reaction condition, free of isomers, free of catalysts and few in three wastes, the synthesis process is extensive, the reaction condition is optimized, the reaction equipment cost is reduced, the produced product is easy to separate, and the production process is simplified. The structural formula (I) is described in the specification.
Preparation method for imidazolinone compound
-
Paragraph 0042; 0047, (2019/03/29)
The invention provides a preparation method for an imidazolinone compound, belongs to the technical field of organic synthesis, and can solve the problems that a large amount of wastewater is producedand the content of impurities in the product is high in the existing process for preparing the imidazolinone compound. According to the preparation method for the imidazolinone compound provided by the invention, a solution of 5-alkyl pyridine-2,3-phthalate is synthesized from ammonium carbonate; the steps of adding water, extracting, refining and the like are avoided in post-treatment; the obtained solution of the 5-alkyl pyridine-2,3-phthalate is used for subsequent reaction; and the wastewater is not produced. Then, a catalyst is added in the process of preparing 5-alkyl pyridine-2,3-dimethylbenzene anhydride, and the pH is controlled in the subsequent reaction process, so that the production of the impurities can be avoided, and the product purity is improved. The imidazolinone compound prepared by the method provided by the invention can be used as a high-efficiency herbicide.
Herbicidal composition
-
, (2008/06/13)
The present invention relates to a herbicidal composition, comprising A) one or more compounds of the formula (I) 1in which Hal1 and Hal2 are identical or different halogen atoms, R1 is H, a cation or a C1-C20-carbon-containing radical and B) one or more surfactants, comprising as structural element at least 12 alkylene oxide units.