104227-38-5Relevant articles and documents
New Syntheses of Some Functionalized and Acetylenic β-Keto Phosphonates
Delamarche, Isabelle,Mosset, Paul
, p. 5453 - 5457 (1994)
β-Keto phosphonates ω-functionalized by an ester group 1a-f, by a hydroxyl 5, and with a triple bond conjugated to the carbonyl group 2a-c were prepared by reacting dimethyl (lithiomethyl)phosphonate (3) with adequate electrophiles.Cyclic anhydrides such as succinic and glutaric anhydrides were employed for the synthesis of the two first homologs 1a and 1b.To obtain the other longer homologs 1c-f, 3-acylthiazolidine-2-thiones 7a-d easily prepared using cheap 2-mercaptothiazoline proved to be the electrophiles of choice.On the other hand, the synthesis of keto phosphonates 2a-c required the use of N-methoxy-N-methylamides.
Chemoselective synthesis of β-ketophosphonates using lithiated α-(trimethylsilyl)methylphosphonate
Specklin, Simon,Cossy, Janine
, p. 3302 - 3308 (2015/03/30)
A highly chemoselective synthesis of β-ketophosphonates from pentafluorophenyl esters and lithiated methyl α-(trimethylsilyl)methylphosphonate has been developed. This mild lithiated phosphonate reagent allows the synthesis of functionalized β-ketophosphonates in the presence of unactivated esters with high yields. This method has been compared with the standard lithiated methylphosphonate reagent.
Total synthesis of a novel isoprostane IPF(2α)-I and its identification in biological fluids
Adiyaman, Mustafa,Lawson, John A.,Hwang, Seong-Woo,Khanapure, Subhash P.,FitzGerald, Garret A.,Rokach, Joshua
, p. 4849 - 4852 (2007/10/03)
The first tokai synthesis of IPF(2α)-I 25 is described using D-glucose as starting material. This novel isoprostane has been used to establish its presence in human urine.
