104579-02-4 Usage
General Description
N4-benzoyl-5-methyldeoxycytidine, also known as tazemetostat, is a synthetic chemical compound that has shown promise in cancer treatment. It is a potent and selective inhibitor of the EZH2 enzyme, which is involved in the regulation of gene expression. Tazemetostat has been found to be effective in inhibiting the growth of cancer cells, particularly in certain types of lymphomas and solid tumors. It is currently being investigated in clinical trials for its potential use in the treatment of various types of cancer, and early results have shown promising anti-tumor activity. Tazemetostat represents a new and potentially valuable tool in the fight against cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 104579-02-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,5,7 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 104579-02:
(8*1)+(7*0)+(6*4)+(5*5)+(4*7)+(3*9)+(2*0)+(1*2)=114
114 % 10 = 4
So 104579-02-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N3O5/c1-10-8-20(14-7-12(22)13(9-21)25-14)17(24)19-15(10)18-16(23)11-5-3-2-4-6-11/h2-6,8,12-14,21-22H,7,9H2,1H3,(H,18,19,23,24)/t12-,13+,14+/m0/s1
104579-02-4Relevant articles and documents
Unexpected shift to a 4-imino tautomer upon N4-acylation of 5- methylcytosin-1-yl nucleoside analogues
Busson,Kerremans,Van Aerschot,Peeters,Blaton,Herdewijn
, p. 1079 - 1082 (1999)
In contrast with the behaviour of 5-unsubstituted cytosine nucleoside analogues, 5-methylcytosine derivatives show upon N4-benzoylation, commonly used as base protection in oligonucleotide synthesis, a tautomeric change of the base moiety from a 4-amino- into a 4-imino isomer. In the latter form, which is easily diagnosticized by 13C NMR and confirmed by X-ray data, the compounds seem to be hydrolytically less stable.
