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10475-06-6

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10475-06-6 Usage

General Description

5-AMINO-2-CHLORO-N,N-DIMETHYL-BENZENESULFONAMIDE is a chemical compound with the molecular formula C8H10ClN2O2S. It is a sulfonamide derivative, which means it contains a functional group consisting of a sulfur atom bonded to an amino group and a benzene ring. 5-AMINO-2-CHLORO-N,N-DIMETHYL-BENZENESULFONAMIDE is commonly used in pharmaceutical research and drug development due to its potential as a therapeutic agent. It has been studied for its antibacterial and anticancer properties, and it may also have applications in the treatment of inflammatory and autoimmune diseases. Additionally, 5-AMINO-2-CHLORO-N,N-DIMETHYL-BENZENESULFONAMIDE is also used as a chemical intermediate in the synthesis of other organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 10475-06-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,7 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10475-06:
(7*1)+(6*0)+(5*4)+(4*7)+(3*5)+(2*0)+(1*6)=76
76 % 10 = 6
So 10475-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H11ClN2O2S/c1-11(2)14(12,13)8-5-6(10)3-4-7(8)9/h3-5H,10H2,1-2H3

10475-06-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Amino-2-chloro-N,N-dimethylbenzenesulfonamide

1.2 Other means of identification

Product number -
Other names N,N-dimethyl-2-chloro-5-aminobenzene-sulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10475-06-6 SDS

10475-06-6Relevant articles and documents

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Xie, Yiyue,Tummala, Padmaja,Oakley, Aaron J.,Deora, Girdhar Singh,Nakano, Yuji,Rooke, Melissa,Cuellar, Matthew E.,Strasser, Jessica M.,Dahlin, Jayme L.,Walters, Michael A.,Casarotto, Marco G.,Board, Philip G.,Baell, Jonathan B.

, p. 2894 - 2914 (2020/04/08)

Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent reactivity of the active-site cysteine has resulted in reported inhibitors that act by covalent labeling. In this study, structure-activity relationship (SAR) elaboration of the reported GSTO1-1 inhibitor C1-27 was undertaken. Compounds were evaluated for inhibitory activity toward purified recombinant GSTO1-1 and for indicators of target engagement in cell-based assays. As covalent inhibitors, the kinact/KI values of selected compounds were determined, as well as in vivo pharmacokinetics analysis. Cocrystal structures of key novel compounds in complex with GSTO1-1 were also solved. This study represents the first application of a biochemical assay for GSTO1-1 to determine kinact/KI values for tested inhibitors and the most extensive set of cell-based data for a GSTO1-1 inhibitor SAR series reported to date. Our research culminated in the discovery of 25, which we propose as the preferred biochemical tool to interrogate cellular responses to GSTO1-1 inhibition.

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