10488-36-5 Usage
Description
Tofenacin hydrochloride, also known as Tofenacin, is a metabolite of Orphenadrine (O695300) and serves as an antidepressant prodrug. It is the active ingredient in the medication with the brand name Tofenacin, which is recognized by the International Nonproprietary Name (INN) and British Approved Name (BAN). Tofenacin hydrochloride exhibits its therapeutic effects by modulating the levels of neurotransmitters in the brain, thus providing relief from the symptoms of depression and other mood disorders.
Uses
Used in Pharmaceutical Industry:
Tofenacin hydrochloride is used as an antidepressant for the treatment of depression and other mood disorders. It works by modulating the levels of neurotransmitters, such as serotonin and norepinephrine, in the brain, which helps alleviate the symptoms of depression and improve the overall mood of the patient.
Used in Research and Development:
Tofenacin hydrochloride is also used as a research compound in the development of new medications and therapies for various psychiatric and neurological disorders. Its unique properties and mechanisms of action make it a valuable tool for understanding the complex interactions between neurotransmitters and their role in mood regulation.
Used in Quality Control and Standardization:
In the pharmaceutical industry, tofenacin hydrochloride is used as a reference standard for quality control and standardization of the active pharmaceutical ingredient (API) in the final drug product. This ensures that the medication meets the required specifications and maintains a consistent level of efficacy and safety.
Used in Ondansetron USP Related Compound C:
Tofenacin hydrochloride is also used in the context of Ondansetron USP Related Compound C, which is a compound related to the antiemetic drug Ondansetron. This application highlights the versatility of tofenacin hydrochloride in various pharmaceutical applications and its potential use in the development of new drugs with similar therapeutic profiles.
Originator
Elamol,Brocades,UK,1971
Manufacturing Process
A mixture of 39.5 grams of 2-methylbenzhydrol, 200 ml of β-chloroethanol
and 10 ml of concentrated hydrochloric acid is boiled under reflux for 4 hours.
After cooling, the reaction mixture is poured into water and extracted with
petroleum ether (boiling range 40° to 60°C). The layers are separated and the
ethereal solution dried with sodium sulfate. It is then filtered. The filtrate is
concentrated by evaporation of the solvent. The residue is distilled under
reduced pressure to give 51.0 grams (yield 98%) of β-chloroethyl-2-
methylbenzhydryl ether, boiling at 156° to 158°C/2.5 mm.
A mixture of 51 grams of β-chloroethyl-2-methylbenzhydryl ether and 35
grams of methylamine in 140 ml of methanol is heated for 6 hours in a closed
vessel at a temperature of 125° to 135°C. After cooling, the reaction mixture
is poured into water and extracted with petroleum ether (boiling range 40° to
60°C). The ether layer is separated and washed with a 2 N hydrochloric acid
solution. The acidic layer is made alkaline and extracted with ether. The
ethereal solution is separated and dried with sodium sulfate. After filtration,
the solvent is evaporated and the residue distilled under reduced pressure.
There is thus obtained 40 grams (yield 80%) of N-methylaminoethyl-2-
methylbenzhydrylether boiling at 139° to 143°C/0.7 mm.
The base is dissolved in anhydrous ether, and an ethereal solution of
hydrochloric acid is added to form the hydrochloride of N-methylaminoethyl-2-
methylbenzhydryl ether. The salt is crystallized from a mixture of ethanol and
ether. Yield is 36 grams (78%); melting point 147° to 148°C.
Therapeutic Function
Psychostimulant
Check Digit Verification of cas no
The CAS Registry Mumber 10488-36-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,8 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10488-36:
(7*1)+(6*0)+(5*4)+(4*8)+(3*8)+(2*3)+(1*6)=95
95 % 10 = 5
So 10488-36-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO.ClH/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H
