1048976-83-5

• 

• Basic information

  1. Product Name: 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER
  2. Synonyms: 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER;1-BENZYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE;1,2,3,6-Tetrahydro-1-(phenylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)boronate;1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine;1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);(1-BENZYL-1,2,3,6-TETRAHYDROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER
  3. CAS NO:1048976-83-5
  4. Molecular Formula: C₁₈H₂₆BNO₂
  5. Molecular Weight: 317.23082
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 1048976-83-5.mol
  9. Article Data: 4

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 357.709 °C at 760 mmHg
  3. Flash Point: 170.137 °C
  4. Appearance: /
  5. Density: 1.05
  6. Refractive Index: N/A
  7. Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  8. Solubility: N/A
  9. PKA: 8.30±0.40(Predicted)
  10. CAS DataBase Reference: 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
  11. NIST Chemistry Reference: 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER(1048976-83-5)
  12. EPA Substance Registry System: 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER(1048976-83-5)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 1048976-83-5(Hazardous Substances Data)

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• 1-BENZYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE

  Cas No: 1048976-83-5

• USD $ 3.0-3.0 / Kilogram

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• 1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

  Cas No: 1048976-83-5

• USD $ 12.0-12.0 / Gram

• 1 Gram

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• Pharmaceutical Grade CAS 1048976-83-5 with competitive price

  Cas No: 1048976-83-5

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• 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER CAS:1048976-83-5

  Cas No: 1048976-83-5

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• 1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

  Cas No: 1048976-83-5

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• 1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester CAS NO.1048976-83-5

  Cas No: 1048976-83-5

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• 1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

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• 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine

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• 1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

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• Suzhou Health Chemicals Co., Ltd.
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• 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER Cas no.1048976-83-5 98%

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1048976-83-5 Usage

General Description

1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester is a boronic acid derivative that is commonly used in organic synthesis and medicinal chemistry. It is a white crystalline solid that is soluble in organic solvents and is stable under normal conditions. This chemical is commonly used as a building block in the synthesis of various pharmaceutical compounds, especially in the development of drugs targeting neurological disorders and cancer. Its boronic acid functionality allows it to form stable complexes with certain biological molecules, making it a valuable tool for the design and development of new drugs and chemical probes. Additionally, this compound is also used as a ligand in various catalytic processes, further adding to its versatility and importance in chemical research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1048976-83-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,8,9,7 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1048976-83:
(9*1)+(8*0)+(7*4)+(6*8)+(5*9)+(4*7)+(3*6)+(2*8)+(1*3)=195
195 % 10 = 5
So 1048976-83-5 is a valid CAS Registry Number.

1048976-83-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine

1.2 Other means of identification

Product number	-
Other names	1-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1048976-83-5 SDS

1048976-83-5Upstream product

• 50-00-0 formaldehyd 
• 70882-08-5 N-benzylbuta-2,3-dien-1-amine 
• 73183-34-3 bis(pinacol)diborane 
• 175347-95-2 N-benzyl-4-bromo-1,2,5,6-tetrahydropyridine 
• 1195-66-0 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 100-44-7 benzyl chloride 
• 181219-01-2 4-pyridineboronic acid pinacol ester 

1048976-83-5Downstream Products

1048976-83-5Relevant articles and documents

Preparation method of N-substituted-tetrahydropyridine-3/4-boric acid/ester

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Paragraph 0023-0025, (2020/04/22)

The invention discloses a preparation method of N-substituted tetrahydropyridine-3/4-boric acid/ester, and belongs to the technical field of organic boric acid chemistry. The method comprises the following steps: carrying out a reaction on pyridine-3/4-boric acid/ester and a halide to form a quaternary salt, and reducing the quaternary salt with sodium/potassium borohydride in an aprotic solvent to generate N-substituted-tetrahydropyridine-3/4-boric acid/ester. According to the method, easily-synthesized pyridine-3/4-boric acid/ester is used as a raw material, the product can be obtained through two continuous steps, and the reaction selectivity is high, so that the defect that palladium-catalyzed coupling or ultralow temperature is needed when substituted piperidone is adopted as a raw material is overcome, the method is verified on the hectogram scale, and a concise and efficient synthesis path is provided for preparation of the compound.

New synthesis method of N-substituted-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester

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Paragraph 0025; 0027-0028, (2019/12/25)

The invention discloses a new synthesis method of N-substituted-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester. The new synthesis method of the N-substituted-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester comprises the following three reaction steps: firstly, performing reaction on 4-bromopyridine hydrochloride and clR1 to prepare 4-bromine-N-substituted-pyridine chloride; then preparing N-substituted-piperidine-4-alkenyl bromide through NaBH4 reduction; finally, preparing the target product N-substituted-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester through a Grignard method and methoxy boric acid ester. The synthesis route has the advantages of high universality, cheap and easily available raw materials, mild reaction condition, few byproducts, high yield andthe like, and the product has high economic property and strong market competitiveness and is suitable for industrialized production. The formula is as shown in the description, wherein R1=-Boc;-Cbz;-Bz;-Bn;-Fmoc;-Me;-Et;-iPr;-Ph.

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