105093-21-8Relevant articles and documents
Isolation and structural elucidation of urinary metabolites of ciprofloxacin
Gau,Kurz,Petersen,Ploschke,Wuensche
, p. 1545 - 1549 (2007/10/02)
After oral administration of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-1-ylqu inoline-3-carboxylic acid (ciprofloxacin, Bay o 9867; designated trademark: Ciprobay) four metabolites M1-M4 were isolated from human urine by Craig counter current distribution and semipreparative high-performance liquid chromatography. Their molecular structures were elucidated by nuclear magnetic resonance and mass spectrometry and confirmed by comparing their spectra with those of authentic synthetic reference compounds.