Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products > 1051375-16-6

CAS: 1051375-16-6

Name:
GSK1349572
Cas No.:
1051375-16-6
Molecular Structure:
Molecular Structure of 1051375-16-6 (GSK1349572)
EINECS(EC#):
Molecular Formula:
C20H19F2N3O5
Molecular Weight:
419.13
Synonyms:
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-;
Chemical
Appearance:
 
mp :
 
bp :
668.958 °C at 760 mmHg
Flash Point:
358.373 °C
Density:
1.532 g/cm3
Water Solubility :
 
Safety Data

Risk Codes:

Safety:

RTECS :

DG0875000

Specification

The GSK1349572, with the CAS registry number 1051375-16-6, is also known as 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-. This chemical's molecular formula is C20H19F2N3O5 and molecular weight is 419.13. What's more, its IUPAC name is called (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. GSK1349572 is an experimental new drug under investigation for the treatment of HIV infection. It is an integrase inhibitor. Studies have shown this chemical to be effective in patients with resistance to the only currently available integrase inhibitor, raltegravir.

Physical properties about GSK1349572 are: (1)ACD/LogP: 0.399; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1.00; (4)ACD/BCF (pH 7.4): 1.00; (5)ACD/KOC (pH 5.5): 5.15; (6)ACD/KOC (pH 7.4): 1.00; (7)#H bond acceptors: 8; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 4; (10)Polar Surface Area: 99.18 Å2; (11)Index of Refraction: 1.65; (12)Molar Refractivity: 99.811 cm3; (13)Molar Volume: 273.775 cm3; (14)Surface Tension: 67.442 dyne/cm; (15)Density: 1.532 g/cm3; (16)Flash Point: 358.373 °C; (17)Enthalpy of Vaporization: 103.285 kJ/mol; (18)Boiling Point: 668.958 °C at 760 mmHg; (19)Vapour Pressure: 0 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: C[C@@H]1CCO[C@@H]2N1C(=O)c3c(c(=O)c(cn3C2)C(=O)NCc4ccc(cc4F)F)O
(2) InChI: InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1
(3) InChIKey: RHWKPHLQXYSBKR-BMIGLBTASA-N

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Prodcuts Directory

Suppliers list

Henan Surface Industry Co Ltd
Telephone: 86-371-86169316
Contact Fax: 86-371-86169316
Website:http://www.surfaceindustry.com
Hangzhou Dayangchem Co., Ltd.
Telephone: +86-571-88938639
Contact Fax: +86-571-88938652
Website:http://www.chinadayangchem.com
Hubei Jusheng Technology Co., Ltd.,
Telephone: +86-27-59599243
Contact Fax: +86-027-83861211
Website:http://www.hubeijusheng.com/
HENAN SUNLAKE ENTERPRISE CORPORATION
Telephone: +86-371- 55366292
Contact Fax: +86-371-86562286
Website:http://www.hnsunlake.com
Baowei Technology(Qinhuangdao)Co., Ltd
Telephone: +86-335-8505079
Contact Fax: +86-335-8505070
Website:www.baoweitech.com
Anyang General Chemical Co.,Ltd.
Telephone: +86-372-5086905
Contact Fax: +86-372-5951936
Website:http://www.lookforchem.com/
Shanghai Yingrui Biopharma Co., Ltd
Telephone: 021-3358 8661*8003
Contact Fax:
Website:www.shyrchem.com
Shandong Zhi Shang Chemical Co.Ltd
Telephone: +86-531-67805312
Contact Fax: +86-531-67809011
Website:http://www.sdzschem.com
Jilin Tely Imp.& Exp.Co., Ltd.
Telephone: 86-431-81915458
Contact Fax: 86-431-81915458
Website:www.jltelyie.com
Shaanxi Mingqi Chemical Co., Ltd
Telephone: 18092428356
Contact Fax:
Website:http://mingqichem.lookchem.com/

Tags:1051375-16-6 Related Product Information