105281-08-1 Usage
Chemical class
Pyrimidine nucleosides
Natural occurrence
Synthetic derivative of arabinosylcytosine
Application
Antiviral and anticancer agent
Structural similarity
Cytosine, a nucleobase in DNA and RNA
Mechanism of action
Inhibits replication of viral and cancer cells by interfering with genetic material
Fluoro substitution
At the 2' position of the arabinose sugar
Enhanced properties
Stability and potency due to fluoro substitution
Importance
Therapeutic agent for certain viral infections and malignancies
Usage
Pharmaceutical formulations and research settings for its pharmacological properties
Check Digit Verification of cas no
The CAS Registry Mumber 105281-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,2,8 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 105281-08:
(8*1)+(7*0)+(6*5)+(5*2)+(4*8)+(3*1)+(2*0)+(1*8)=91
91 % 10 = 1
So 105281-08-1 is a valid CAS Registry Number.
105281-08-1Relevant articles and documents
Nucleosides. 139. Synthesis and Anticytomegalovirus and Antiherpes Simplex Virus Activity of 5'-Modified Analogues of 2'-Fluoroarabinosylpyrimidine Nucleosides
Harada, Kazuho,Matulic-Adamic, Jasenka,Price, Richard W.,Schinazi, Raymond F.,Watanabe, Kyoichi A.,Fox, Jack J.
, p. 226 - 229 (2007/10/02)
In order to determine if modification of the 5'-position reduces or abolishes the antiviral activity of 2'-fluoro-5-iodo-ara-C (FIAC), 2'-fluoro-5-iodo-ara-U (FIAU), or 2'-fluoro-5-methyl-ara-U (FMAU) against human cytomegalovirus (HCMV) and herpes simple
