105467-77-4 Usage
General Description
1,2,3,4-Tetrahydrodibenzo(a,j)acridine is a chemical compound with a unique polycyclic structure that is used in various medical and research applications. It is a potent inhibitor of DNA topoisomerase II, an essential enzyme for DNA replication and repair. 1,2,3,4-TETRAHYDRODIBENZ(A,J)ACRIDINE has been studied for its potential anticancer properties, as it has been shown to induce tumor cell death by disrupting DNA structure and function. Additionally, 1,2,3,4-tetrahydrodibenzo(a,j)acridine has also been investigated for its potential as an anti-malarial agent due to its ability to inhibit the growth of Plasmodium falciparum parasites. However, this compound is also known to be toxic and mutagenic, so care must be taken when handling and using it in laboratory settings.
Check Digit Verification of cas no
The CAS Registry Mumber 105467-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,4,6 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 105467-77:
(8*1)+(7*0)+(6*5)+(5*4)+(4*6)+(3*7)+(2*7)+(1*7)=124
124 % 10 = 4
So 105467-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H17N/c1-3-7-16-14(5-1)9-11-20-18(16)13-19-17-8-4-2-6-15(17)10-12-21(19)22-20/h1,3,5,7,9-13H,2,4,6,8H2
105467-77-4Relevant articles and documents
Synthesis of Potential Metabolites of Dibenzacridine: Dihydro Diols and Phenols
Rosario, Christopher A.,Holder, Gerald M.,Duke, Colin C.
, p. 1064 - 1072 (2007/10/02)
The potential trans dihydro diol metabolites of the carcinogen dibenzacridine (1) were prepared.The dihydro diols trans-1,2-dihydroxydibenzacridine (12) and trans-3,4-dihydro-3,4-dihydroxydibenzacridine (13) were prepared by Prevost reactio