105659-32-3Relevant articles and documents
Transglycosylation in the Modification and Isotope Labeling of Pyrimidine Nucleosides
Gong, Yong,Chen, Lu,Zhang, Wei,Salter, Rhys
supporting information, p. 5577 - 5581 (2020/07/24)
Transglycosylation of pyrimidine nucleosides is demonstrated in a one-pot synthesis of uridine derivatives under microwave irradiation. Inductive activation of 2′,3′,5′-tri-O-acetyl uridine with a 5-nitro group produces a more-reactive glycosyl donor. Under optimized Vorbrüggen conditions, the 5-nitrouridine facilitates a reversible nucleobase exchange with a series of 5-substituted uracils. The protocol is also exemplified in a gram-scale reaction under thermal heating. The strategy provides easy access to isotopically labeled uridine.
Alternative nucleic acid molecules and uses thereof
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, (2015/11/09)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
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, (2016/06/28)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
