105746-38-1

• 

• Basic information

  1. Product Name: N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine
  2. Synonyms: N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine;CMPHSKQRGJSKJX-QGZVFWFLSA-N
  3. CAS NO:105746-38-1
  4. Molecular Formula: C₁₉H₂₁NO₃
  5. Molecular Weight: 311.37494
  6. EINECS: N/A
  7. Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
  8. Mol File: 105746-38-1.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 520.7±50.0 °C(Predicted)
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: 1.159±0.06 g/cm3(Predicted)
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. PKA: 3.80±0.10(Predicted)
  10. CAS DataBase Reference: N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine(CAS DataBase Reference)
  11. NIST Chemistry Reference: N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine(105746-38-1)
  12. EPA Substance Registry System: N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine(105746-38-1)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 105746-38-1(Hazardous Substances Data)

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• Downstream Products
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105746-38-1 Usage

Uses

N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine is an oral hypoglycemic agent used in the treatment of non-insulin dependant diabetes mellitus.

Check Digit Verification of cas no

The CAS Registry Mumber 105746-38-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,7,4 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 105746-38:
(8*1)+(7*0)+(6*5)+(5*7)+(4*4)+(3*6)+(2*3)+(1*8)=121
121 % 10 = 1
So 105746-38-1 is a valid CAS Registry Number.

105746-38-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-(4-Isopropylphenylcarbonyl)-D-phenylalanine

1.2 Other means of identification

Product number	-
Other names	N--[4-(1-Methylethyl)benzoyl]-D-phenylalanine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105746-38-1 SDS

105746-38-1Upstream product

• 21900-62-9 p-isopropylbenzoyl chloride 
• 673-06-3 D-(R)-phenylalanine 
• 21685-51-8 D-phenylalanine methyl ester 
• 536-66-3 p-isopropylbenzoic acid 

105746-38-1Downstream Products

105746-38-1Relevant articles and documents

N-(Cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. 2

Shinkai,Nishikawa,Sato,Toi,Kumashiro,Seto,Fukama,Dan,Toyoshoma

, p. 1436 - 1441 (2007/10/02)

A series of analogues of N-(cyclohexylcarbonyl)-D-phenylalanine (5) have been synthesized and evaluated for their hypoglycemic activity. Relationships were studied between the activity and the three-dimensional structure of the acyl moiety, which was characterized by high-resolution 1H NMR spectroscopy and MNDO calculations. The role of the carboxyl group of the phenylalanine moiety was also studied by comparing the activities of the enantiomers, the decarboxyl derivative, the esters, and the amides of the phenylalanine derivatives. Thus, the structural requirements for possessing hypoglycemic activity was elucidated and a highly active compound, N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine (13) was obtained, which showed a 20% blood glucose decrease at an oral dose of 1.6 mg/kg in fasted normal mice.

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