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1059-14-9

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1059-14-9 Usage

Uses

4-Taraxasterol can be used to promote apoptosis in leukemic cells, as well as screening for antiviral activity against SARS-CoV-2 and related corona viruses.

Definition

ChEBI: A pentacyclic triterpenoid that is taraxastane with a beta-hydroxy group at position 3.

Check Digit Verification of cas no

The CAS Registry Mumber 1059-14-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,5 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1059-14:
(6*1)+(5*0)+(4*5)+(3*9)+(2*1)+(1*4)=59
59 % 10 = 9
So 1059-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21?,22?,23?,24+,25?,27-,28+,29-,30-/m1/s1

1059-14-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name taraxasterol

1.2 Other means of identification

Product number -
Other names Taraxasterin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1059-14-9 SDS

1059-14-9Related news

Optimization of methyl jasmonate and β-cyclodextrin for enhanced production of taraxerol and Taraxasterol (cas 1059-14-9) in (Taraxacum officinale Weber) cultures08/02/2019

ContextTaraxacum officinale Weber (TO) commonly known as “dandelion”, is a tropical Asian medicinal plant which contains taraxasterol (TX) and taraxerol (TA) in its roots, which are reported to be commercially important anticancer compounds.detailed

Effects of Taraxasterol (cas 1059-14-9) on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages08/01/2019

Ethnopharmacological relevanceTaraxasterol was isolated from the Chinese medicinal herb Taraxacum officinale which has been frequently used as a remedy for inflammatory diseases. Our previous study has shown that taraxasterol inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prost...detailed

Effects of Taraxasterol (cas 1059-14-9) on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages07/31/2019

Aim of the studyTaraxasterol, a pentacyclic-triterpene, was isolated from the Chinese medicinal herb Taraxacum officinale. In the present study, we investigated the in vitro anti-inflammatory activity of taraxasterol in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages.detailed

Protective effect of Taraxasterol (cas 1059-14-9) on acute lung injury induced by lipopolysaccharide in mice07/30/2019

Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been reported to have potent anti-inflammatory properties. However, the effect of taraxasterol on lipopolysaccharide (LPS)-induced mice acute lung injury has not been investigated. The aims of this study were to inves...detailed

Effects of Taraxasterol (cas 1059-14-9) on ovalbumin-induced allergic asthma in mice07/29/2019

Ethnopharmacological relevanceTaraxasterol was isolated from the Chinese medicinal herb Taraxacum officinale which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo protective effect of taraxasterol on allergic asthma induced by ovalb...detailed

Taraxasterol (cas 1059-14-9) inhibits cigarette smoke-induced lung inflammation by inhibiting reactive oxygen species-induced TLR4 trafficking to lipid rafts07/28/2019

Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been demonstrated to have anti-inflammatory effects. However, the protective effects of taraxasterol against cigarette smoke (CS)-induced lung inflammation have not been reported. This study aimed to investigate the p...detailed

Taraxasterol (cas 1059-14-9) inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes07/27/2019

Osteoarthritis (OA), a chronic degenerative joint disease, is a leading cause of disability among elderly patients. Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been shown to have anti-inflammatory effects. However, the protective effect of taraxasterol on OA re...detailed

Anti-inflammatory and anti-arthritic effects of Taraxasterol (cas 1059-14-9) on adjuvant-induced arthritis in rats07/26/2019

Ethnopharmacological relevanceTaraxasterol was isolated from the traditional Chinese medicinal herb Taraxacum which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo anti-arthritic effect of taraxasterol on arthritis induced by Freund...detailed

Taraxasterol (cas 1059-14-9) suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice07/25/2019

Previous study has indicated that taraxasterol (TAR), one of bioactive pentacyclic triterpenes mainly isolated from Chinese medicine herb Taraxacum officinale, displays considerable anti-inflammatory effects in various kinds of models. However, its effects on rheumatoid arthritis (RA) have still...detailed

Network pharmacology-based identification of the protective mechanisms of Taraxasterol (cas 1059-14-9) in experimental colitis07/24/2019

Background and aimTaraxasterol, a pentacyclic-triterpene, has been reported to exert potent anti-inflammatory activity. However, the molecular mechanisms by which taraxasterol attenuates acute experimental colitis (AEC) remain undocumented.detailed

1059-14-9Relevant articles and documents

Carbon-13 Resonance Assignments of some Friedelanes and Taraxasteranes

Patra, Amarendra,Mukhopadhyay, Apurba K.,Mitra, Alok K.

, p. 166 - 168 (1981)

Carbon-13 signal assignments of taraxasteryl acetate, taraxasteryl palmitate, taraxasterol and epi-friedenyl acetate are reported.Some signal assignments of the friedelanones, reported recently by others, are inconsistent and require revision.

Antispasmodic and spasmogenic effects of Scolymus hispanicus and taraxasteryl acetate on isolated ileum preparations

Kirimer, Nes'E,Tunalier, Zeynep,Baser, K. Huesnue Can,Cingi, Ipek

, p. 556 - 558 (1997)

Taraxasteryl acetate (1) was identified as the major triterpenoid of the ethanolic extract of the root bark of Scolymus hispanicus L. Antispasmodic and spasmogenic effects of the ethanolic extract, its fractions, taraxasteryl acetate, and a fluid extract of this plant were tested on isolated rat ileum preparations. The strong biphasic responses observed suggested a possible lithuretic activity of the compounds and the fractions tested.

Terpenoids in four Inula species from Bulgaria

Aneva, Ina,Ivanova, Victoria,Staleva, Plamena,Todorova, Milka,Trendafilova, Antoaneta

, p. 1229 - 1240 (2022/02/16)

Phytochemical study of the chloroform extract of the aerial parts of Inula germanica L., I. ensifolia L., I. conyza (Griess.) DC. and I. salicina L. led to the identification of 33 terpenoids. β- and α-amyrin, lupeol, taraxasterol, ψ-taraxasterol and their 3-O-acetates and 3-O-palmitates were identified by GC/MS. In addition, the structures of 3-O-palmitates of mainaladiol, arnidiol, faradiol and 16-hydroxylupeol were confirmed by NMR. ent-Kaur-16-en-19- -oic acid and its 15α-(3-methylpentanoyloxy) and 15α-(3-methylbutanoyloxy) derivatives were isolated from I. conyza. Ten closely related sesquiterpene lactones (germacranolides and melampolides) were found in I. germanica and their structural identification was performed by spectral analyses. I. ensifolia and I. salicina were free of sesquiterpene lactones and diterpenoids. All triterpenoids and diterpenoids, grazielia acid, desacetylovatifolin and 8-(2-methylbutanoyloxy)- 1(10),4,11(13)-germacrutrien-6,12-olide-14-oic acid are described for the first time in the studied species. The principal component analysis was used to find a relationship between the investigated up to now Inula species, growing in Bulgaria.

Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol

Segura, Michael J. R.,Meyer, Michelle M.,Matsuda, Seiichi P. T.

, p. 2257 - 2259 (2007/10/03)

lupeol lupeol, germanicol, synthase β-amyrin, taxasterol, oxidosqualene → ψ-taraxasterol, and 3,20-dihydroxylupane The Arabidopsis thaliana LUP1 gene encodes an enzyme that converts oxidosqualene to pentacyclic triterpenes. Lupeol and β-amyrin were previously reported as LUP1 products. Further investigation described here uncovered the additional products germanicol, taraxasterol, ψ-taraxasterol, and 3,20-dihydroxylupane. These results suggest that the 80 known C30H50O compounds that are structurally consistent with being oxidosqualene cyclase products may be derived from fewer than 80 enzymes and that some C30H52O2 compounds may be direct cyclization products of oxidosqualene.

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