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10590-10-0

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10590-10-0 Usage

Uses

Deacetylcephalothin Lactone (Cefalotin EP Impurity D) is an impurity in the synthesis of Cefalonium (C236800), a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows.

Check Digit Verification of cas no

The CAS Registry Mumber 10590-10-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,9 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10590-10:
(7*1)+(6*0)+(5*5)+(4*9)+(3*0)+(2*1)+(1*0)=70
70 % 10 = 0
So 10590-10-0 is a valid CAS Registry Number.

10590-10-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-yl)-2-thiophen-2-yl-acetamide

1.2 Other means of identification

Product number -
Other names 7β-(2-thiophen-2-yl-acetylamino)-cephalosporadesic acid lactone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10590-10-0 SDS

10590-10-0Downstream Products

10590-10-0Relevant articles and documents

Progress towards a stable cephalosporin-halogenated phenazine conjugate for antibacterial prodrug applications

Xiao, Tao,Liu, Ke,Huigens, Robert W.

, (2020)

Resistant bacteria successfully evade the action of conventional antibiotic therapies during infection, often leading to significant illness and death. Our lab has discovered halogenated phenazine (HP) analogues which demonstrate potent antibacterial activities through a unique iron-starving mechanism. Herein, we describe synthetic efforts towards a stable cephalosporin-HP conjugate prodrug with the aim of translating HPs into useful clinical agents. Cephalosporin-antibiotic conjugates offer multiple advantages for antibacterial design, including the release of active agents through the targeting of intracellular cephalosporinase following selective ring-opening of the beta-lactam warhead. During these studies, carbonate-linked cephalosporin-HP conjugate 16 was synthesized; however, we were unable to successfully remove the ester group required for cephalosporinase processing. Cephalosporin-HP 16 was then utilized as a probe to investigate the stability of the carbonate linker in antibacterial assays and, as predicted, this compound proved to be inactive against Staphylococcus aureus (MIC > 100 μM). The lack of 16’s antibacterial activity can be attributed to the carbonate linker remaining intact throughout the MIC assay, thus not liberating the active HP moiety. These efforts have led to a more stable cephalosporin-HP conjugate joined through a carbonate linker compared to a highly unstable ether linked analogue we previously reported.

Preparation method of cefoxitin lactone

-

Paragraph 0016; 0044; 0047-0050; 0051; 0054; 0055; 0058, (2020/02/08)

The invention discloses a preparation method of a cefoxitin lactone. The method comprises the following steps: (1) under catalysis of N,O-bis(trimethylsilyl)acetamide or triethylamine, 2-thiopheneacetyl chloride and 7-ACA are subjected to an amidation reaction in an organic solvent to obtain a compound 2; (2) the compound 2 is subjected to a hydrolysis reaction under enzyme catalysis to obtain an[(6R,7R)-3-methylol-8-oxo-7-(2-thiopheneacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid] compound 1; and (3) the compound 1 is subjected to an intramolecular esterification reaction in an alcohol solvent under the action of an acid, and after the reaction is completed, the cefoxitin lactone is obtained by post-treatment. The preparation method has mild reaction conditions, simpleoperation, and high reaction yield, and the obtained cefoxitin lactone has high purity, and can be used as an impurity reference substance in the process of drug consistency re-research.

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