106566-58-9 Usage
Uses
AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.
Biological Activity
Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release.
references
[1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392.
Check Digit Verification of cas no
The CAS Registry Mumber 106566-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,6 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 106566-58:
(8*1)+(7*0)+(6*6)+(5*5)+(4*6)+(3*6)+(2*5)+(1*8)=129
129 % 10 = 9
So 106566-58-9 is a valid CAS Registry Number.
106566-58-9Relevant articles and documents
REACTIONS OF TELLURIUM TETRAHALIDES WITH GLYCOLS
Zingaro, Ralph A.,Pathirana, Hema M. K. K.,Reibenspies, Joseph H.,Meyers, Edward A.
, p. 91 - 99 (2007/10/02)
Tellurium tetrahalides undergo reaction with glycols to yield three different products: O,O'-dioxotrihalotellurates; bis(alkoxy)dihalotellurium(IV) compounds and hexahalotellurates.The course of the reaction appears to be determined primarily by the natur
