108827-19-6 Usage
General Description
(R)-4-Amino-3-(naphthalen-1-yl)butanoic acid, also known as (R)-Napabta or R-Napabta, is a chemical compound with a molecular formula C16H17NO2. It is a chiral amino acid derivative, consisting of a naphthyl group attached to a butyric acid backbone. (R)-Napabta has been studied for its potential use in pharmaceuticals and organic synthesis. It acts as a selective agonist for the GABAB receptor, which makes it a possible candidate for the treatment of central nervous system disorders and chronic pain. Additionally, the compound has shown potential as an anti-inflammatory agent. Its unique structure and pharmaceutical properties make (R)-4-Amino-3-(naphthalen-1-yl)butanoic acid a subject of interest for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 108827-19-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,8,2 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 108827-19:
(8*1)+(7*0)+(6*8)+(5*8)+(4*2)+(3*7)+(2*1)+(1*9)=136
136 % 10 = 6
So 108827-19-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H15NO2/c15-9-11(8-14(16)17)13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11H,8-9,15H2,(H,16,17)/t11-/m0/s1
108827-19-6Relevant articles and documents
Tritiated Peptides. Part 15. Synthesis of Tritium Labelled Biologically Active Analogues of Somatostatin
Allen, Mark C.,Brundish, Derek E.,Fullerton, Joseph D.,Wade, Roy
, p. 989 - 1004 (2007/10/02)
The syntheses are described of cyclo-8,Gaba12>somatostatin-(5-12)-peptide> (77), and (79)-(82) labelled singly at positions 6, 7, 8, and 11 and doubly at residues 6 and 11 to specific radioactivities of between 4.8 and 22.4 Ci mmol-1.The linear sequence (5-12) and the related cyclo8,Nag12>somatostatin-(5-12)-peptide> (78) and (83) were also prepared to specific radioactivities of 19.2 and 19.6 Ci mmol-1 respectively.The syntheses of the labelled hexapeptide cyclo-7,D-Trp8,Pro12>somatostatin-(7-12)-peptide> (84) and full sequences 6,D-Trp8,D-Cys14>somatostatin (94) and 8,4-(3)H-Phe11,D-Cys14>somatostatin (95) labelled at ca. 13.0 Ci mmol-1 are described.Labelling was effected by reductive dehalogenation in the presence of tritium of the fully protected precursors and the purity of the final products was assessed by amino acid analysis after acidic hydrolysis following purification by ion-exchange and h.p.l.c. as appropriate.
