109792-60-1Relevant articles and documents
A new perylene bisimide bola amphiphile: Synthesis, characterization, fluorescent properties and applications as a potential probe
Franceschin, Marco,Bombelli, Cecilia,Borioni, Silvia,Bozzuto, Giuseppina,Eleuteri, Silvia,Mancini, Giovanna,Molinari, Agnese,Bianco, Armandodoriano
, p. 2166 - 2173 (2013)
Fluorescently-tagged lipids are a powerful tool for investigating the dynamics of lipids in cell biological studies and in biophysical applications. Herein we report the synthesis and the characterization of a new bola amphiphile, PC12, based on a bisimidic perylene moiety: a central perylene unit is symmetrically linked to two aliphatic chains both ending with a quaternary ammonium group. Absorption and fluorescent properties of the newly synthesized compound were investigated in DMSO and in water as a function of concentration and temperature. Further, the entrapment efficiency, the fluorescence behavior in dimyristoyl-sn-glycero-phosphocholine (DMPC) liposomes, and cell uptake on human and murine glioblastoma cell lines were evaluated. When loaded in liposomes, PC12 follows the same destiny of liposomes themselves in the cell cultures: this is an interesting result because PC12 could be used both as an aspecific dye (free form) and as an organelle-specific lipid probe.
Solvent-dependent self-assembly and morphological transition of low-molecular-weight azobenzene organogel
Zhang, Zhiwei,Zhang, Shaoze,Zhang, Junji,Zhu, Liangliang,Qu, Dahui
, p. 4891 - 4895 (2017)
A novel low molecular weight organogelator (LMOG) containing an azobenzene group has been designed and synthesized. Stable gels could be formed in various organic solvents. UV–Vis spectroscopy indicated that the sol-gel transition of the organogels could be reversibly tuned by UV/visible light irradiations. Importantly, scanning electron microscopy (SEM) revealed that the characteristic gelation morphologies would vary from solvents of different polarities. FT-IR, XRD and rheological measurements demonstrated that the different nanostructures in polar and non-polar solvents might result from the differences in the intermolecular hydrogen bonding, π-π stacking driving forces as well as the different stacking models for the formation of the gels. Moreover, as an efficient phase-selective gelator, this photo-switchable gel could perform as an efficient absorbent and water cleaner to remove pollutants (e.g. rhodamine B).
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures
Morrell, Andrew,Placzek, Michael S.,Steffen, Jamin D.,Antony, Smitha,Agama, Keli,Pommier, Yves,Cushman, Mark
, p. 2040 - 2048 (2007)
Indenoisoquinolines with lactam substituents such as ethylamino, propylamino, and butylamino have previously demonstrated potent biological activity, but an optimal length has never been established. In the present study, a series of simplified indenoisoquinoline analogues possessing a linker spacing of 0-12 carbon atoms between the lactam nitrogen and the terminal amino group have been prepared, determining that 2-4-atom lengths are optimal for topoisomerase I inhibition and cytotoxicity. Using these lengths, analogues were prepared with the amino group and portions of the linker replaced by a pyridine ring. A three-carbon spacer within the pyridine series still demonstrated potent topoisomerase I inhibition.
Efficient phosphodiester cleaving nanozymes resulting from multivalency and local medium polarity control
Diez-Castellnou, Marta,Mancin, Fabrizio,Scrimin, Paolo
supporting information, p. 1158 - 1161 (2014/02/14)
The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tu
