11029-61-1

• 

• Basic information

  1. Product Name: GRAMICIDIN A
  2. Synonyms: OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH;OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONHCH2CH2OH;GA;HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH;HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH;HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH;GRAMICIDIN A;GRAMICIDIN A, BACILLUS BREVIS
  3. CAS NO:11029-61-1
  4. Molecular Formula: C99H140N20O17
  5. Molecular Weight: 1882.29
  6. EINECS: 234-259-8
  7. Product Categories: Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Mechanism of Action;Peptides;Spectrum of Activity
  8. Mol File: 11029-61-1.mol
  9. Article Data: 0

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: colorless or white/
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: 2-8°C
  8. Solubility: ethanol: soluble
  9. BRN: 6461131
  10. CAS DataBase Reference: GRAMICIDIN A(CAS DataBase Reference)
  11. NIST Chemistry Reference: GRAMICIDIN A(11029-61-1)
  12. EPA Substance Registry System: GRAMICIDIN A(11029-61-1)

• Safety Data

  1. Hazard Codes: Xn
  2. Statements: 22
  3. Safety Statements: N/A
  4. WGK Germany: 3
  5. RTECS: MD8230000
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 11029-61-1(Hazardous Substances Data)

• Suppliers
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• SDS
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11029-61-1 Suppliers

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• Factory Price API 99% GRAMICIDIN A 11029-61-1 GMP Manufacturer

  Cas No: 11029-61-1

• USD $ 0.1-0.1 / Gram

• 1 Gram

• 100 Metric Ton/Year

• Xi'an Xszo Chem Co., Ltd.
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• Pharmaceutical Grade CAS 11029-61-1 with competitive price

  Cas No: 11029-61-1

• USD $ 139.0-210.0 / Kilogram

• 1 Kilogram

• 1000 Kilogram/Day

• Zhuozhou Wenxi import and Export Co., Ltd
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• Gramicidin A

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• Medicine Raw Materials Gramicidin a CAS 11029-61-1

  Cas No: 11029-61-1

• USD $ 1.0-10.0 / Gram

• 1 Gram

• 200 Metric Ton/Day

• Hebei Nengqian Chemical Import and Export Co., LTD
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• Gramicidin A

  Cas No: 11029-61-1

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• 10 Gram

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• TaiChem Taizhou Limited
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• 99% up by HPLC GRAMICIDIN A 11029-61-1

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• Sinoway Industrial Co., Ltd.
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• Grimicidin A (High Purity), Bacillus brevis

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• Antimex Chemical Limied
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• Gramicidin A

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• Shanghai Run-Biotech Co., Ltd.
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11029-61-1 Usage

Uses

Gramicidin A is an effective antibiotic against Gram positive organisms.

Purification Methods

Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]

Check Digit Verification of cas no

The CAS Registry Mumber 11029-61-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,2 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 11029-61:
(7*1)+(6*1)+(5*0)+(4*2)+(3*9)+(2*6)+(1*1)=61
61 % 10 = 1
So 11029-61-1 is a valid CAS Registry Number.

InChI:InChI=1/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83+,84+,85-/m0/s1

11029-61-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	GRAMICIDIN A

1.2 Other means of identification

Product number	-
Other names	HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:11029-61-1 SDS

11029-61-1Upstream product

11029-61-1Downstream Products

11029-61-1Related news

Mixed Langmuir monolayers of GRAMICIDIN A (cas 11029-61-1) and fluorinated alcohols08/23/2019

Mixed monolayers of gramicidin A (GA) and three alcohols, differing in the degree of fluorination, namely C18OH, F18OH, and F8H10OH have been investigated by means of: surface manometry (π–A isotherms) and Brewster angle microscopy (BAM) aiming at finding appropriate molecules for incorporatin...detailed

Ion channel stability of GRAMICIDIN A (cas 11029-61-1) in lipid bilayers: Effect of hydrophobic mismatch08/22/2019

Hydrophobic mismatch which is defined as the difference between the lipid hydrophobic thickness and the peptide hydrophobic length is known to be responsible in altering the lipid/protein dynamics. Gramicidin A (gA), a 15 residue β helical peptide which is well recognized to form ion conducting...detailed

pH-Dependent properties of ion channels formed by N-terminally glutamate substituted GRAMICIDIN A (cas 11029-61-1) in planar lipid bilayers08/20/2019

The N-terminally glutamate substituted analogue of the pentadecapeptide gramicidin A [Glu1]gA has been previously described as a low-toxic uncoupler of mitochondrial oxidative phosphorylation and neuroprotector. Here, we studied ion channel-forming activity of this peptide in planar bilayer lipi...detailed

Neuroprotective effect of glutamate-substituted analog of GRAMICIDIN A (cas 11029-61-1) is mediated by the uncoupling of mitochondria08/19/2019

BackgroundReactive oxygen species are grossly produced in the brain after cerebral ischemia and reperfusion causing neuronal cell death. Mitochondrial production of reactive oxygen species is nonlinearly related to the value of the mitochondrial membrane potential with significant increment at v...detailed

ArticleMembrane Elastic Deformations Modulate GRAMICIDIN A (cas 11029-61-1) Transbilayer Dimerization and Lateral Clustering08/18/2019

Gramicidin A (gA) is a short β-helical peptide known to form conducting channels in lipid membranes because of transbilayer dimerization. The gA conducting dimer, being shorter than the lipid bilayer thickness, deforms the membrane in its vicinity, and the bilayer elastic energy contributes to ...detailed

Bioactivity of topologically confined GRAMICIDIN A (cas 11029-61-1) dimers08/17/2019

The d-/l-peptide gramicidin A (gA) is well known as a pivotal ion channel model and shows a broad spectrum of bioactivities such as antibiosis, antimalarial activity, as well as hemolysis. We applied inter-chain disulfide bonds to constrain the conformational freedom of gA into parallel and anti...detailed

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