1111637-81-0 Usage
General Description
2-(2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile is a chemical compound with the molecular formula C10H8N4OS. It is a pyrimidine derivative with a nitrile group and a methylthio substituent at the 2 and 4 positions, respectively. 2-(2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile is commonly used in pharmaceutical research and drug development as it has shown potential biological activities and therapeutic effects. Its precise functions and uses are still under investigation within the scientific community. Due to its molecular structure and properties, 2-(2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile has the potential to be used in the development of new drugs targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1111637-81-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,1,6,3 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1111637-81:
(9*1)+(8*1)+(7*1)+(6*1)+(5*6)+(4*3)+(3*7)+(2*8)+(1*1)=110
110 % 10 = 0
So 1111637-81-0 is a valid CAS Registry Number.
1111637-81-0Relevant articles and documents
MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
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, (2017/01/31)
The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
