111555-58-9 Usage
Description
NALTRIBEN MESYLATE is a potent and selective antagonist specifically designed to target the δ2 opioid receptor. It is a pharmaceutical compound that plays a crucial role in differentiating between the δ1 and δ2 opioid receptors, which are essential for understanding the complex interactions within the opioid system.
Uses
Used in Pharmaceutical Research and Development:
NALTRIBEN MESYLATE is used as a research tool for investigating the roles and functions of δ1 and δ2 opioid receptors. Its selective antagonism allows scientists to study the individual contributions of these receptors in various physiological and pathological processes, leading to a better understanding of the opioid system and the development of more targeted therapies.
Used in Pain Management:
NALTRIBEN MESYLATE is used as a potential therapeutic agent for pain management, particularly in cases where the δ2 opioid receptor is involved. By selectively blocking the δ2 receptor, it may help to alleviate pain without causing the same side effects associated with non-selective opioid receptor antagonists.
Used in Addiction Treatment:
NALTRIBEN MESYLATE is used as a potential treatment option for individuals struggling with opioid addiction. Its selective antagonism of the δ2 receptor may help to reduce cravings and withdrawal symptoms, making it a valuable tool in the fight against opioid dependence and addiction.
Used in Drug Delivery Systems:
Similar to gallotannin, NALTRIBEN MESYLATE can also be incorporated into drug delivery systems to enhance its efficacy and bioavailability. These systems may include organic and metallic nanoparticles, which serve as carriers for the compound, improving its delivery to target tissues and cells.
Biological Activity
Selective and potent δ -opioid receptor antagonist (K i values are 0.013, 19 and 152 nM for δ , μ and κ receptors respectively). Displays selectivity for the δ 2 subtype in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 111555-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,5,5 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 111555-58:
(8*1)+(7*1)+(6*1)+(5*5)+(4*5)+(3*5)+(2*5)+(1*8)=99
99 % 10 = 9
So 111555-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1
111555-58-9Relevant articles and documents
N-OXIDES OF 4,5-EPOXY-MORPHINANIUM ANALOGS
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Page/Page column 140-141, (2009/06/27)
Novel N-oxides of 4,5-epoxy-morphinanIum analogs are disclosed. Pharmaceutical compositions containing the N-oxides of 4,5-epoxy-morphinanium analogs and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.
Application of the message-address concept in the design of highly potent and selective non-peptide δ opioid receptor antagonists
Portoghese,Sultana,Nagase,Takemori
, p. 281 - 282 (2007/10/02)
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