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Low price with good quality Gatifloxacin Carboxyclic Acid
Cas No: 112811-72-0
USD $ 100.0-150.0 / Kilogram
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Lonwin Chemical Group Limited
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High purity 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid CAS:112811-72-0
Cas No: 112811-72-0
USD $ 100.0-500.0 / Gram
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Hangzhou Dingyan Chem Co., Ltd
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High quality 1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinoline Carboxylic Acid supplier in China
Cas No: 112811-72-0
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Simagchem Corporation
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8-methoxy-1-cyclopropyl-6 7-difluoro-1 4-dihydro-4-oxo-3-quinolinecarboxylic acid CAS 112811-72-0
Cas No: 112811-72-0
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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd
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High quality 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Cas 112811-72-0 with best price
Cas No: 112811-72-0
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Wuhan Fortuna Chemical Co.,Ltd
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Factory Supply 1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinoline Carboxylic Acid
Cas No: 112811-72-0
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Ality Chemical Corporation
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High Quality 99% 112811-72-0 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Manufacturer
Cas No: 112811-72-0
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Xi'an Xszo Chem Co., Ltd.
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1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
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Anhui Dexinjia Biopharm Co., Ltd
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1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Cas No: 112811-72-0
USD $ 5.0-5.0 / Kilogram
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Enke Pharma-tech Co.,Ltd. （Cangzhou, China ）
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Gatifloxacin acid in stock
Cas No: 112811-72-0
USD $ 4.0-4.0 / Kilogram
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Dayang Chem (Hangzhou) Co.,Ltd.
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112811-72-0 Usage

Chemical Properties

Off-White to Light-Yellow Powder

Uses

Different sources of media describe the Uses of 112811-72-0 differently. You can refer to the following data:
1. Moxifloxacin intermediate
2. Moxifloxacin intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 112811-72-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,1 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 112811-72:
(8*1)+(7*1)+(6*2)+(5*8)+(4*1)+(3*1)+(2*7)+(1*2)=90
90 % 10 = 0
So 112811-72-0 is a valid CAS Registry Number.

InChI:InChI=1/C14H11F2NO4/c1-21-13-10(16)9(15)4-7-11(13)17(6-2-3-6)5-8(12(7)18)14(19)20/h4-6H,2-3H2,1H3,(H,19,20)

112811-72-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

1.2 Other means of identification

Product number	-
Other names	1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112811-72-0 SDS

112811-72-0Synthetic route

: 112811-71-9
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 65℃; for 15h; Solvent; Temperature;	96.83%
With sulfuric acid; acetic acid In water for 2h; Reflux;	95.92%
With hydrogenchloride for 3h; Heating;	90%

: 154093-72-8
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid

: 77-78-1
dimethyl sulfate

A: 141290-02-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid methyl ester

B: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With potassium chloride In acetone Product distribution / selectivity; Heating / reflux;

: 141290-02-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid methyl ester

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With water; potassium carbonate for 0.5h; Product distribution / selectivity; Heating / reflux;

: 112811-70-8
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With sodium fluoride In N,N-dimethyl-formamide
Multi-step reaction with 2 steps 1: sodiumfluoride / N,N-dimethyl-formamide / 5 h 2: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-64-0
2,4,5-trifluoro-3-methoxy-benzamide

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: sulfuric acid / 3.5 h / 100 °C 2: thionyl chloride / 3 h 3: magnesium ethylate / toluene 4: toluene-4-sulfonic acid / water / 9 h 5: acetic anhydride / 11 h 6: ethanol / 2 h / 20 °C 7: sodiumfluoride / N,N-dimethyl-formamide / 5 h 8: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-63-9
3-methoxy-2,4,5-trifluorobenzonitrile

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: sulfuric acid; water / 1 h / 110 °C 2: sulfuric acid / 3.5 h / 100 °C 3: thionyl chloride / 3 h 4: magnesium ethylate / toluene 5: toluene-4-sulfonic acid / water / 9 h 6: acetic anhydride / 11 h 7: ethanol / 2 h / 20 °C 8: sodiumfluoride / N,N-dimethyl-formamide / 5 h 9: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-67-3
diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / water / 9 h 2: acetic anhydride / 11 h 3: ethanol / 2 h / 20 °C 4: sodiumfluoride / N,N-dimethyl-formamide / 5 h 5: sulfuric acid; water / acetic acid / 1 h View Scheme

: 13332-24-6
1-bromo-2,4,5-trifluoro-3-methoxybenzene

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C 2: sulfuric acid; water / 1 h / 110 °C 3: sulfuric acid / 3.5 h / 100 °C 4: thionyl chloride / 3 h 5: magnesium ethylate / toluene 6: toluene-4-sulfonic acid / water / 9 h 7: acetic anhydride / 11 h 8: ethanol / 2 h / 20 °C 9: sodiumfluoride / N,N-dimethyl-formamide / 5 h 10: sulfuric acid; water / acetic acid / 1 h View Scheme

Yield

Multi-step reaction with 10 steps
1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C
2: sulfuric acid; water / 1 h / 110 °C
3: sulfuric acid / 3.5 h / 100 °C
4: thionyl chloride / 3 h
5: magnesium ethylate / toluene
6: toluene-4-sulfonic acid / water / 9 h
7: acetic anhydride / 11 h
8: ethanol / 2 h / 20 °C
9: sodiumfluoride / N,N-dimethyl-formamide / 5 h
10: sulfuric acid; water / acetic acid / 1 h
View Scheme

: 112811-65-1
3-methoxy-2,4,5-trifluorobenzoic acid

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: thionyl chloride / 3 h 2: magnesium ethylate / toluene 3: toluene-4-sulfonic acid / water / 9 h 4: acetic anhydride / 11 h 5: ethanol / 2 h / 20 °C 6: sodiumfluoride / N,N-dimethyl-formamide / 5 h 7: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-66-2
2,4,5-trifluoro-3-methoxybenzoyl chloride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: magnesium ethylate / toluene 2: toluene-4-sulfonic acid / water / 9 h 3: acetic anhydride / 11 h 4: ethanol / 2 h / 20 °C 5: sodiumfluoride / N,N-dimethyl-formamide / 5 h 6: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-68-4
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: acetic anhydride / 11 h 2: ethanol / 2 h / 20 °C 3: sodiumfluoride / N,N-dimethyl-formamide / 5 h 4: sulfuric acid; water / acetic acid / 1 h View Scheme

: 122375-85-3
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ethanol / 2 h / 20 °C 2: sodiumfluoride / N,N-dimethyl-formamide / 5 h 3: sulfuric acid; water / acetic acid / 1 h View Scheme

: 530-62-1
1,1'-carbonyldiimidazole

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 869310-07-6
1-cyclopropyl-6,7-difluoro-3-(imidazole-1-carbonyl)-8-methoxy-1H-quinolin-4-one

Conditions

Conditions	Yield
In tetrahydrofuran Heating / reflux;	100%
In chloroform Heating / reflux;	100%
In tetrahydrofuran Heating / reflux;	100%
In tetrahydrofuran Heating / reflux;	100%

: 11113-50-1
boric acid

: 108-24-7
acetic anhydride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 139693-52-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate

Conditions

Conditions	Yield
Stage #1: boric acid; acetic anhydride With potassium hydroxide; zinc(II) chloride at 100℃; for 12h; Stage #2: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid at 50℃; for 1h; Concentration; Temperature; Reagent/catalyst;	97.4%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 847233-56-1
1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at 20 - 66℃; for 6.08333h;	97%
With boron trifluoride diethyl etherate; potassium carbonate In tetrahydrofuran at 20 - 66℃; Inert atmosphere;	97%
With BF3OEt In various solvent(s) Cyclization; Heating;	83%
With boron trifluoride diethyl etherate In tetrahydrofuran for 36h; Heating / reflux;
Multi-step reaction with 2 steps 1: acetonitrile / 1 h / 70 - 80 °C / Inert atmosphere; Large scale 2: 1 h / 0 - 15 °C / Large scale View Scheme

: 109-63-7
boron trifluoride diethyl etherate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: (1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: boron trifluoride diethyl etherate In tetrahydrofuran at 60℃; for 6h; Temperature; Reagent/catalyst;	97%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C18H18F2N2O3

Conditions

Conditions	Yield
In toluene at 105 - 115℃; Temperature; Solvent; Inert atmosphere; Industrial scale;	96.6%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 151096-09-2
moxifloxacin

Conditions

Conditions	Yield
With [BCl2(4-picoline)][AlCl4]; triethylamine In methanol at 85℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;	96%
In dimethyl sulfoxide at 65 - 70℃; for 6 - 8h;	89.7%
With triethylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 78℃; for 11h; Reflux;	66%

: 151213-42-2
[R,R]-2,8-diazabicyclo[4.3.0]nonane

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: moxifloxacin

Conditions

Conditions	Yield
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.416667h; Reflux;	96%
at 150℃; Microwave irradiation;	83%

: 4887-24-5
triacetoxyborane

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-(O3,O4)-bis-(acetate-O)borate

Conditions

Conditions	Yield
In water at 0 - 90℃; for 4h;	95.3%

: 3-methylaminopiperidine dihydrochloride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-(3-methylaminopiperidin-1-yl)-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 3-methylaminopiperidine dihydrochloride; 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 26h; Stage #2: With methanol for 6h; Reflux; Stage #3: With sodium hydroxide In methanol; water at 20℃; for 16h; pH=8;	92%
With triethylamine In acetonitrile

: 13264-88-5, 66918-24-9, 75336-85-5, 75336-89-9, 93334-99-7
(+/-)-2-methylpiperazine bis(hydrochloride)

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 160738-57-8, 112811-59-3
gatifloxacin

Conditions

Conditions	Yield
Stage #1: (+/-)-2-methylpiperazine bis(hydrochloride); 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 25h; Stage #2: With methanol for 5h; Reflux; Stage #3: With sodium hydroxide In methanol; water at 20℃; for 16h; pH=7;	91%

: 87-69-4
L-Tartaric acid

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 1082245-30-4
L(+)-moxifloxacin tartrate

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In N,N-dimethyl-formamide at 65 - 70℃; for 6 - 8h; Stage #2: L-Tartaric acid In N,N-dimethyl-formamide at 25 - 80℃; for 13 - 16h; Product distribution / selectivity;	90.32%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 154093-72-8
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; calcium chloride In water; dimethyl sulfoxide at -5 - 25℃; for 3.5h; pH=4;	90%
With hydrogen bromide; acetic acid at 100℃; for 24h;
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With hydrogen bromide In acetic acid at 100℃; for 1h; Stage #2: With water In acetic acid at 0℃;
With hydrogen bromide; acetic acid at 100℃; for 24h;

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 186826-86-8
moxifloxacin hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With titanium(IV) isopropylate; triethylamine In isopropyl alcohol at 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In methanol at 20℃; for 1h; pH=1; Solvent; Reagent/catalyst;	90%
Multi-step reaction with 2 steps 1: Alkaline conditions 2: hydrogenchloride View Scheme
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 85℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 15℃; for 1h; pH=1.4 - 1.8; Inert atmosphere;	3.3 g

: 21850-12-4
cycloperhydroisoindole

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-2H-isoindol-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 24h; Reflux;	89%

: 123-75-1
pyrrolidine

: 121-43-7
Trimethyl borate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(pyrrolidin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In ethanol; acetonitrile	88.2%

: 660-68-4
diethyl amine hydrochloride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1028205-74-4
1-cyclopropyl-N,N-diethyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 10 - 35℃; Inert atmosphere;	87.3%

: 882-33-7
diphenyldisulfane

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6,7-difluoro-8-methoxy-3-(phenylthio)quinolin-4(1H)-one

Conditions

Conditions	Yield
With palladium diacetate; triphenylphosphine; silver carbonate In dimethyl sulfoxide at 130℃; for 12h; Schlenk technique;	87%

: 121-43-7
Trimethyl borate

: 79286-87-6
(RS)-3-(acetyl-methyl-amino)-pyrrolidine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-[3-(N-acetyl-N-methylamino)pyrrolidino]pyrrolidino-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
In ethanol; acetonitrile	83.9%

: C14H18N2O2S

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C28H28FN3O6S

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h;	82.3%

: 109-07-9
(RS)-2-methylpiperazine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 160738-57-8, 112811-59-3
gatifloxacin

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 76 - 80℃; for 1h; Heating / reflux; Stage #2: With boron trifluoride diethyl etherate In acetonitrile at 0 - 25℃; for 2h; Stage #3: (RS)-2-methylpiperazine With triethylamine In acetonitrile at 15 - 25℃; for 3h; pH=~ 9;	81.8%
In dimethyl sulfoxide at 55℃; for 24h;	66%
In dimethyl sulfoxide at 60 - 65℃; for 29 - 45h;	53.7%
In dimethyl sulfoxide at 20 - 73℃; for 13.9167 - 14.3333h;	52%
In dimethyl sulfoxide at 70 - 95℃; for 2h;

: C26H26N2

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C40H36FN3O4

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h;	81.8%

: C12H20N2O2

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C26H30FN3O6

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h;	81.5%

: C7H9N3O2

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1018938-14-1
C21H19FN4O6

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	79%

: 177-11-7
4,4-ethylenedioxy-piperidine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 848070-83-7
1-cylopropyl-7-(1,4-dioxa-8-aza-spiro[4,5]dec-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	73%

: 2744-08-3, 2744-09-4, 6329-61-9
decahydroisoquinoline

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydroisoquinolin-2(1H)-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 24h; Reflux;	73%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 721970-36-1
1-cyclopropyl-6-fluoro-8-hydroxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With isobutylamine; copper dichloride In methanol; ethylene glycol at 50℃; for 4h; Inert atmosphere; Stage #2: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In methanol; ethylene glycol for 5h; Reflux; Stage #3: With sodium hydroxide In methanol; water; ethylene glycol for 1h; Reflux;	72.1%

: 123-90-0
Thiomorpholin

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 114213-99-9
1-Cyclopropyl-6-fluoro-8-methoxy-7-thiomorpholino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	70%

: 3367-95-1
N,N-diethylpiperidine-3-carboxamide

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1018937-94-4
C24H30FN3O5

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	70%

112811-72-0Upstream product

112811-72-0Downstream Products

112811-72-0Relevant articles and documents

Synthesis and crystal structure of 1-cyclopropyl-6,7-difluoro-8-methoxy-4- oxo-1,4-dihydro-3-quinoline carboxylic acid-(O3,O4)-bis-(acetate-O)borate

Li, Fei,Zhang, Jie,Jiang, Yu,Jin, Lei,Zhang, Chuan

, p. 6079 - 6082 (2013)

The crystal structure of the 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1, 4-dihydro-3-quinoline carboxylic acid-(O3,O4)-bis-(acetate-O)borate has been determined by single crystal X-ray diffraction method. The crystal belongs to monoclinic with space group P2(1)/n, with a = 16.818(9), b = 6.585(4), c = 18.663(4)?, a = 90, b = 107.351(7), g = 90, V = 1972.8(18)?3, Z = 4, Dx = 1.479 Mg/m3, l(MoKa) = 0.128, F(000) = 908, ?(MoKa) = 0.128 mm-1, R = 0.1083 and wR = 0.3062 for 2378 reflections with I > 2s(I). The two rings of fluoroquinolone and borate ring are almost coplanar with dihedral angles values lower than 2. The crystal structure is stabilized by intermolecular hydrogen bonds and p-p stacking interactions.

Compound and preparation method thereof

-

Paragraph 0067; 0068; 0069, (2018/03/24)

The invention provides a compound and a preparation method of the compound, wherein the compound has the structure as shown in the formula 1, and the compound is taken as a standard substance or a reference substance, therefore, the quality of moxifloxacin raw medicines and preparation products can be effectively controlled.

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β

Cociorva, Oana M.,Li, Bei,Nomanbhoy, Tyzoon,Li, Qiang,Nakamura, Ayako,Nakamura, Kai,Nomura, Masahiro,Okada, Kyoko,Seto, Shigeki,Yumoto, Kazuhiro,Liyanage, Marek,Zhang, Melissa C.,Aban, Arwin,Leen, Brandon,Szardenings, Anna Katrin,Rosenblum, Jonathan S.,Kozarich, John W.,Kohno, Yasushi,Shreder, Kevin R.

scheme or table, p. 5948 - 5951 (2011/10/18)

The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone- 3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this class were potent and highly selective GSK-3 inhibitors.

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112811-72-0

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112811-72-0Synthetic route

112811-72-0Upstream product

112811-72-0Downstream Products

112811-72-0Relevant articles and documents

Synthesis and crystal structure of 1-cyclopropyl-6,7-difluoro-8-methoxy-4- oxo-1,4-dihydro-3-quinoline carboxylic acid-(O3,O4)-bis-(acetate-O)borate

Li, Fei,Zhang, Jie,Jiang, Yu,Jin, Lei,Zhang, Chuan

, p. 6079 - 6082 (2013)

Compound and preparation method thereof

-

Paragraph 0067; 0068; 0069, (2018/03/24)

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β

scheme or table, p. 5948 - 5951 (2011/10/18)