113741-01-8Relevant articles and documents
(2-aminoethyl)-N hydrofluorination compd. manufacturing method
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Paragraph 0034, (2016/12/12)
PROBLEM TO BE SOLVED: To provide a method for preparing an N-(2-aminoethyl)azole compound, which is a preparation method offering short reaction time, high purification efficiency of a final product, high production efficiency and high safety because a reaction solution undergoes no heat generation or rise of liquid level caused by bubbling. SOLUTION: The method for preparing the N-(2-aminoethyl)azole compound comprises reacting an azole-based compound (A) and an ethylamine derivative (B) having a leaving group at position 2 in the presence of a base (C) in a solvent (D) so as to prepare the N-(2-aminoethyl)azole compound. Here, the ethylamine derivative (B) having the leaving group at position 2 is fed to the reaction system in portions while the reaction system is maintained at 50-200°C. COPYRIGHT: (C)2010,JPOandINPIT
Benzoxazole carboxamides for treating CINV and IBS-D
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Page/Page column 6, (2008/06/13)
Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.