1138-67-6Relevant articles and documents
Biotransformation of diphenyl ether by the yeast Trichosporon beigelii SBUG 752
Schauer, Frieder,Henning, Kirsten,Pscheidl, Helmut,Wittich, Rolf M.,Fortnagel, Peter,et al.
, p. 173 - 180 (2007/10/03)
Trichosporon beigelii SBUG 752 was able to transform diphenyl ether. By TLC, HPLC, GC, GC-MS, NMR- and UV-spectroscopy, several oxidation products were identified. The primary attack was initiated by a monooxygenation step, resulting in the formation of 4-hydroxydiphenyl ether, 2-hydroxydiphenyl ether and 3-hydroxydiphenyl ether (48:47:5). Further oxidation led to 3,4-dihydroxydiphenyl ether. As a characteristic product resulting from the cleavage of an aromatic ring, the lactone of 2-hydroxy-4-phenoxymuconic acid was identified. The possible mechanism of ring cleavage to yield this metabolite is discussed.