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113853-16-0

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113853-16-0 Usage

General Description

2-Amino-Oxazole-5-Carboxylic Acid Ethyl Ester is a chemical compound generally used in the field of organic chemistry. It's primarily used as a reagent or building block in a range of pharmaceutical and medicinal applications. The compound contains functional groups such as a carboxylic acid ester, an oxazole ring and an amino group, thereby indicating it can undergo various chemical reactions. As is common with many organic compounds, handling should be done with caution as it may pose certain hazards. However, it’s important to note that detailed information concerning its properties, toxicology, and safety measures still needs comprehensive study.

Check Digit Verification of cas no

The CAS Registry Mumber 113853-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,8,5 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 113853-16:
(8*1)+(7*1)+(6*3)+(5*8)+(4*5)+(3*3)+(2*1)+(1*6)=110
110 % 10 = 0
So 113853-16-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O3/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3,(H2,7,8)

113853-16-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 2-aminooxazole-5-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 2-amino-1,3-oxazole-5-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113853-16-0 SDS

113853-16-0Relevant articles and documents

Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands

Murár, Miroslav,Dobia?, Juraj,?ramel, Peter,Addová, Gabriela,Hanquet, Gilles,Bohá?, Andrej

supporting information, p. 754 - 761 (2016/12/16)

Background Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing in cancer. CLK family kinases are also involved in alternative splicing and RNA processing in Duchenne muscular dystrophy, Alzheimer's disease, HIV-1, and influenza virus. Small inhibitors are valuable tools for better understanding the molecular mechanisms of splicing and may serve as seeds for a novel class of therapeutics. Achievements Here we describe a discovery of four novel CLK1 inhibitors possessing N-aryloxazol-2-amine skeleton. Their activity against CLK1 (IC50: 20, 30, 40 and 80 nM) and some other CMGC kinases, predicted CLK binding poses, synthesis and physico-chemical characteristics are also stated. Additionally analysis of all PDB available CLK structures and interactions of their ligands was performed. There are only few powerful dual CLK/VEGFR inhibitors known in the literature. We proposed that our inhibitors have similar binding places and interactions in CLK1, 3 and VEGFR2 TK mostly due to the joint N-aryloxazol-2-amine pharmacophoric fragment. One of our N-aryloxazol-2-amines already proved a good activity against both VEGFR2 and CLK1 enzymes (23/80 nM, resp). We proposed that the presented class of compounds has a potential to be developed in dual VEGFR2/CLK clinical compounds with prospective synergy to treat cancer.

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